加巴喷丁治疗酒依赖的临床疗效

Clinical Efficacy of Gabapentin in the Treatment of Alcohol Dependence

目的观察加巴喷丁治疗酒精依赖的临床疗效。方法选取2018年2月~2019年2月我院收治的酒依赖患者82例,采用随机数字表法分为加巴喷丁组和安慰剂组,每组41例。加巴喷丁组予加巴喷丁胶囊治疗,安慰剂组予无药物成分的模拟胶囊治疗,比较两组治疗前和治疗后2、4、8、12周强制性饮酒问卷(OCDS)、宾夕法尼亚酒精渴求量表(PACS)及副反应量表(TESS)评分。结果治疗后2周,加巴喷丁组OCDS、PACS评分与安慰剂组比较,差异无统计学意义(P>0.05);治疗后4、8、12周,加巴喷丁组OCDS评分、PACS评分低于安慰剂组[(52.64±1.56)分vs(53.68±1.86)分、(18.62±5.22)分vs(24.34±5.65)分]、[(49.31±1.32)分vs(51.62±1.93)分、(15.14±4.15)分vs(23.92±4.86)分]、[(46.52±1.43)分vs(51.62±1.93)分、(14.71±5.67)分vs(23.92±4.86)分],差异有统计学意义(P<0.05);治疗后4、8、12周,两组TESS评分比较,差异无统计学意义(P>0.05)。结论加巴喷丁可有效减少饮酒行为,降低渴求度,且耐受性好,不良反应轻微。

Objective To observe the clinical efficacy of gabapentin in the treatment of alcohol dependence.Methods A total of 82 patients with alcohol dependence who were admitted to our hospital from February 2018 to February 2019 were randomly divided into the gabapentin group and the placebo group,with 41 cases in each group.The gabapentin group was treated with gabapentin capsules,and the placebo group was treated with no drug-containing simulating capsules.The two groups were treated before and after the 2,4,8 and 12 weeks of mandatory drinking questionnaire(OCDS)and the Pennsylvania Alcohol Thirsty Scale(PACS)and the side reaction scale(TESS)score.Results At 2 weeks after treatment,the OCDS and PACS scores of the gabapentin group were not significantly different from those of the placebo group(P>0.05).At 4,8,and 12 weeks after treatment,the OCDS score and PACS score of the gabapentin group were lower than those of the placebo group[(52.64±1.56)points vs(53.68±1.86)points,(18.62±5.22)points vs(24.34±5.65)points],[(49.31±1.32)points vs(51.62±1.93)points,(15.14±4.15)points Vs(23.92±4.86)points],[(46.52±1.43)points vs(51.62±1.93)points,(14.71±5.67)points vs(23.92±4.86)points],the difference was statistically significant(P<0.05);At 4,8 and 12 weeks after treatment,the TESS scores of the two groups were not significantly different(P>0.05).Conclusion Gabapentin can effectively reduce alcohol consumption,reduce craving,and is well tolerated with mild adverse reactions.