探讨老年免疫性肝炎患者临床检验特点

To Explore the Clinical Test Characteristics of Elderly Patients with Immune Hepatitis

目的探究老年免疫性肝炎患者的临床检验特点,以便在临床检验工作中将有价值的参考依据有效获得。方法选取140例在2018年2月-2019年2月该院收治的免疫性肝炎患者,根据患者年龄,将其分为非老年组(年龄小于60岁)和老年组(年龄≥60岁),两组人数分别为70例。分别检测两组患者的免疫学指标和生化指标,同时统计分析检测结果。结果老年组患者合并类风湿性关节炎者发生率(11.43%)及合并干燥综合征者发生率(35.71%)均明显高于非老年组(χ2=9.174、8.765,P<0.05),合并自身免疫性甲状腺炎者发生率(7.14%)低于非老年组(χ2=9.657,P<0.05);在生化指标检测方面,两组患者血清AST和血清ALT水平差差异有统计学意义(t=12.106、13.034,P<0.05),血清GGT和血清ALP水平差异无统计学意义(t=1.357、0.528,P>0.05)。结论在免疫学指标方面,相比于非老年组患者,老年免疫性肝炎患者与其存在的差异不明显,然而红细胞MCH、MCA水平均存在异常情况,主要原因可能在于患者有自身免疫性胃炎合并发生。因此在临床诊疗和检验工作中,需要高度重视此方面的问题。

Objective To explore the clinical test characteristics of elderly patients with immune hepatitis, so as to obtain valuable reference in clinical laboratory work. Methods A total of 140 patients with immunological hepatitis admitted to our hospital from February 2018 to February 2019 were selected. According to the age of the patients, they were divided into non-elderly group(age less than 60 years old) and elderly group(age over or equal to 60 years old), with70 cases in each group. The immunological and biochemical indicators of the two groups were detected, and the results were statistically analyzed. Results The incidence of rheumatoid arthritis(11.43%) and the incidence of patients with dry syndrome(35.71%) in the elderly group were significantly higher than those in the non-elderly group(χ2=9.174,8.765,P<0.05). The incidence of autoimmune thyroiditis(7.14%) was lower than that of non-elderly group(χ2=9.657,P<0.05). In the detection of biochemical indicators, serum AST and serum ALT levels were statistically significantly different between the two groups(t=12.106, 13.034, P<0.05). There was no statistically significant difference in serum GGT and serum ALP levels between the two groups(t=1.357, 0.528, P>0.05). Conclusion In terms of immunological parameters, compared with non-elderly patients, the difference between elderly patients with immunological hepatitis is not obvious. However, there are abnormalities in MCH and MCA levels in red blood cells. The main reason may be that patients have autoimmune gastritis. Therefore, in clinical diagnosis and examination work, it is necessary to attach great importance to this aspect.