奥美拉唑联合铝碳酸镁治疗胃溃疡合并胃出血效果分析

Efficacy of Omeprazole Combined with Magnesium Bicarbonate in the Treatment of Gastric Ulcer Complicated with Gastric Hemorrhage

目的分析奥美拉唑联合铝碳酸镁治疗胃溃疡合并胃出血患者的临床效果。方法选取2017年4月-2018年11月该院收治的(79)例胃溃疡合并胃出血患者作为研究对象,根据治疗方式不同将其分为观察组(40)例,对照组(39)例,两组分别采用不同治疗方法治疗,对照组单纯使用奥美拉唑治疗,观察组采用奥美拉唑联合铝碳酸镁治疗,对采用和不同方式治疗的两组患者临床治疗效果,不良反应发生情况,幽门螺旋杆菌(Hp)根除情况进行观察记录。结果观察组临床治疗总有效率为95.00%显著高于对照组(64.10%),差异有统计学意义(χ2=11.672,P=0.001),不良反应总发生率情况观察组(5.00%)显著少于对照组(23.08%),差异有统计学意义(χ2=5.384,P=0.020),观察组临床腹部压痛缓解时间为(12.42±1.65)d显著短于对照组(16.85±1.54)d(t=12.329,P<0.001)、呕血黑便缓解时间为(11.64±1.87)d显著短于对照组(15.96±1.28)d(t=11.952,P<0.001)、胃出血缓解时间(12.92±2.19)d显著短于对照组(17.56±1.67)d (t=10.570,P<0.001);观察组Hp根除率为(92.50%)显著高于对照组(74.36%),差异有统计学意义(χ2=4.727,P=0.030)。结论奥美拉唑联合铝碳酸镁治疗效果较为显著,显著优于单纯奥美拉唑。

objectives To study the clinical effect of the treatment of the patients with gastric ulcer with the combination of aluminum magnesium carbonate and aluminum magnesium carbonate.Methods 79 patients with gastric ulcer and gastric hemorrhage admitted to our hospital from April 2017 to November 2018 were selected as the research objects.According to the different treatment methods, they were divided into observation group(40 cases) and control group(39 cases). The two groups were treated with different treatment methods respectively. The control group was treated with omeprazole alone, while the observation group was treated with omeprazole combined with magnesium aluminium carbonate. The clinical efficacy, adverse reactions and eradication of Helicobacter pylori(Hp) were observed and recorded in the two groups.Results The total effective rate of clinical treatment in the observation group(95.00%) was significantly higher than that in the control group(64.10%). The difference statistically was significant(χ2=11.672, P=0.001).The total incidence of adverse reactions in the observation group(5.00%) was significantly lower than that in the control group(23.08%). The difference was statistically significant(χ2=5.384, P=0.020). The relief time of clinical abdominal tenderness in the observation group was significantly shorter than that in the control group(12.42±1.65) d. The remission time of hematemesis and blackstool in group(16.85±1.54) d(t=12.329, P<0.001), hematemesis and blackstool(11.64±1.87) d was significantly shorter than that in control group(15.96±1.28)d,(t=11.952, P<0.001), gastric bleeding remission time(12.92±2.19) d was significantly shorter than that in control group(17.56±1.67) d,(t=10.570, P<0.001);the eradication rate of Hp in observation group(92.50%) was significantly higher than that in control group(74.36%).The difference was statistically significant(χ2=4.727, P=0.030).Conclusion Omeprazole combined with magnesium aluminate is more effective than omeprazole alone.