不同剂量阿托伐他汀钙片治疗缺血性脑血管病的临床疗效

Clinical Efficacy of Different Doses of Atorvastatin Calcium Tablets in the Treatment of Ischemic Cerebrovascular Disease

目的分析缺血性脑血管病采用不同剂量阿托伐他汀钙片治疗的临床疗效。方法随机将该院2016年6月-2018年10月收治的140例缺血性脑血管病患者分为两组,两组均睡前口服阿托伐他汀钙片治疗,但用药剂量不同,对照组用药剂量为20 mg,观察组为40 mg,对比两组患者治疗前后颈部血管斑块、血脂水平变化情况以及用药安全性。结果观察组治疗6个月后斑块面积、斑块厚度以及斑块长度均小于对照组,差异有统计学意义(t=12.636 9、9.632 6、11.036 5,P<0.05);观察组治疗6个月后LDL-C、TG、TC均低于对照组,HDL-C高于对照组,差异有统计学意义(t=5.633 9、9.636 2、11.025 8、3.167 9,P<0.05);对照组不良反应发生率为1.43%(1/70),观察组为2.86%(2/70),差异无统计学意义(χ2=0.588 9,P>0.05)。结论缺血性脑血管病采用40 mg托伐他汀钙片治疗在逆转颈部血管斑块、降脂方面更具优势,且用药安全性高。

Objective To analyze the clinical effect of different doses of atorvastatin calcium tablets in the treatment of ischemic cerebrovascular disease. Methods A total of 140 patients with ischemic cerebrovascular disease admitted to our hospital from June 2016 to October 2018 were randomly divided into two groups. Both groups orally took atorvastatin calcium tablets before going to bed. The dosage of atorvastatin calcium tablets in the two gorups was different. The dosage of atorvastatin calcium tablets was 20 mg in the control group and 40 mg in the observation group. The vascular plaques, blood lipid levels and medication safety of the two groups were compared before and after treatment. Results The area, thickness and length of the plaque in the observation group were smaller than those in the control group after6 months of treatment. And the difference between the two groups was significant(t=12.636 9, 9.632 6, 11.036 5, P<0.05). LDL-C, TG and TC in the observation group were lower than those in the control group after 6 months of treatment, and HDL-C was higher than those in the control group. And the difference between the two groups was significant(t=5.633 9, 9.636 2, 11.025 8, 3.167 9, P<0.05). The incidence of adverse reactions was 1.43%(1/70) in the observation group and 2.86%(2/70) in the observation group, with no significant difference(χ2=0.588 9, P>0.05). Conclusion The treatment of ischemic cerebrovascular disease with 40 mg of atorvastatin calcium tablets has more advantages in reversing cervical vascular plaque and reducing blood lipid, with high safety.