养正合剂在肿瘤化疗患者中的应用与价值评估

Application and Value Evaluation of Yangzheng Mixture in Tumor Chemotherapy Patients

目的评估养正合剂在肿瘤化疗患者中的应用价值。方法 2017年11月-2018年11月该院收治行化疗治疗的恶性肿瘤患者120例,按照入院时间将120例肿瘤化疗患者分为两组,对照组60例进行常规放化疗,观察组在进行常规放化疗的同时联合养正合剂治疗,对比两组肿瘤化疗患者治疗前后的血象指标(血小板计数、白细胞计数、中性粒细胞计数、血红蛋白计数)、不良症状(乏力、食欲、睡眠、消瘦、恶心)的改变情况。结果研究结果显示,两组肿瘤化疗患者化疗前、第1次化疗后的4项血象指标对比,差异无统计学意义(P>0.05)。观察组第2次化疗后的血象指标均高于对照组[第2次化疗,白细胞计数:(4.68±1.23)×10^9/L vs (3.98±0.98)×10^9/L;中性粒细胞计数:(2.79±0.96)×10^9/L vs(2.23±0.91)×10^9/L;血红蛋白计数:(113.65±13.27)g/L vs (107.21±12.88)g/L;血小板计数,(158.87±54.27)×10^9/L vs (133.27±55.16)×10^9/L]差异有统计学意义(t=7.887 1、12.003 3、10.992 3、15.992 3),观察组第3次化疗后的血项指标均高于对照组,差异有统计学意义(P<0.05)。两组肿瘤化疗患者的化疗过程中与化疗后的乏力、食欲、睡眠、消瘦、恶心5项不良症状评分比较,差异有统计学意义(P<0.05)。结论养正合剂在肿瘤化疗患者中应用,能够改善患者的血象,改善患者的不良症状,值得在临床进一步推广应用。

Objective To evaluate the application and value of Yangzheng mixture in tumor chemotherapy patients.Methods A total of 120 patients with malignant tumor treated with chemotherapy in our hospital from November 2017 to November 2018 were selected. According to the admission time, 120 patients with malignant tumor were divided into two groups. The control group(n=60) received conventional radiotherapy and chemotherapy, and the observation group(n=60) was treated with routine radiotherapy and chemotherapy combined with Yangzheng mixture. The hematological indexes(platelet count, white blood cell count, neutrophil count, hemoglobin count), and changes in adverse symptoms(fatigue, appetite, sleep, emaciation, nausea) were compared between the two groups before and after chemotherapy.Results The results showed that there was no significant difference in the four hematological indexes before and after the first chemotherapy between the two groups(P>0.05). The hematological indexes of the observation group after the second chemotherapy were higher than those of the control group [white blood cell count:(4.68±1.23)×10^9/L vs(3.98±0.98)×10^9/L, neutrophil count:(2.79±0.96)×10^9/L vs(2.23±0.91)×10^9/L, hemoglobin count:(113.65±13.27)g/L vs(107.21±12.88)g/L, platelet count:(158.87±54.27)×10^9/L vs(133.27±55.16)×10^9/L], the difference wa sstatistically significant(t=7.887 1, 12.003 3, 10.992 3, 15.992 3). The indexes of hematological indexes after the third chemotherapy in the observation group were higher than those in the control group, and the difference was statistically significant(P<0.05). The scores of fatigue, appetite, sleep, emaciation and nausea were significantly different in the two groups between the course and after the course of chemotherapy(P<0.05). Conclusion The application of Yangzheng mixture in patients with tumor chemotherapy can improve the hematology and symptoms of patients. It is worth further popularizing in clinic.