中药马齿苋+PPI与标准四联根治幽门螺杆菌疗效及对血清G17及PG的影响

Effect of Purslane Combined with PPI and Standard Quadruple Radical Therapy on Helicobacter Pylori, Serum G17 and PG

目的探讨中药马齿苋+质子泵抑制剂(PPI)与标准四联根治幽门螺杆菌(Hp)的临床疗效及对血清胃泌素17(G17)及胃蛋白酶原(PG)的影响。方法收集该院于2018年2月-2019年2月收治的100例Hp阳性的慢性胃病患者。随机数字表法分为A、B组,各50例。A组采用标准四联疗法,B组采用中药马齿苋+PPI疗法,比较各组的临床疗效及药物不良反应发生率及各组治疗前后血清G17及PG表达水平。结果 A组(总有效率80.00%)明显低于B组(总有效率94.00%),差异有统计学意义(χ2=4.332,P=0.037)。治疗前两组血清指标均无差异,治疗后两组的血清G17、PGⅡ水平均降低,PGⅠ、PGⅠ/Ⅱ水平均升高。A组血清G17 (233.67±90.15)ng/L,高于B组血清G17 (194.35±91.32)ng/L,差异有统计学意义(t=2.167,P=0.033);A组PGⅠ(180.43±85.01)ng/L低于B组PGⅠ(216.42±82.56)ng/L,差异有统计学意义(t=2.148,P=0.034);A组PGⅠ/Ⅱ(18.20±4.13)低于B组PGⅠ/Ⅱ(20.21±4.12),差异有统计学意义(t=2.436,P=0.017);两组的PGⅡ水平差异无统计学意义(P>0.05)。A组的药物不良反应发生率(38.00%)明显高于B组(14.00%),差异有统计学意义(χ2=7.484,P=0.006)。结论中药马齿苋+PPI疗法可提高Hp的根除率,降低药物不良反应的发生率,并降低血清G17,改善PG水平。

Objective To investigate the clinical efficacy of purslane combined with proton pump inhibitor(PPI) and standard quadruple radical eradication of helicobacter pylori(Hp) and its effect on serum Gastrin-17(G17) and Pepsinogen(PG). Methods A total of 100 cases of chronic gastric diseases with positive Hp admitted to our hospital from February 2018 to February 2019 were selected. By random number table method, they were divided into group A and group B, 50 cases in each group. Group A was treated with standard quadruple therapy, while group B was treated with purslane + PPI. The clinical efficacy, adverse drug reactions and the levels of serum G17 and PG were compared before and after treatment. Results The total effective rate of group A(80.00%) was significantly lower than group B(94.00%),the difference was statistically significant(χ2=4.332, P=0.037). There were no differences in serum indexes between the two groups before treatment. After treatment, in the two groups, serum G17 and PGII levels decreased, and PGI and PGI/II levels increased. Serum G17 in group A(233.67±90.15)ng/L was higher than that in group B(194.35±91.32)ng/L,the difference was statistically significant(t=2.167, P=0.033). The difference between the two groups was significant. PGI in group A(180.43±85.01)ng/L was lower than that in group B(216.42±82.56)ng/L,the difference was statistically significant(t=2.148, P=0.034), and the difference was significant. PGI/II in group A(18.20±4.13) was lower than that in group B(20.21±4.12),and the difference was significant(t=2.436, P=0.017). There was no significant difference in PGII levels between the two groups(P>0.05). The incidence of adverse drug reactions in group A(38.00%)was significantly higher than that in group B(14.00%),the difference was statistically significant(χ~2=7.484, P=0.006).Conclusion Purslane combined with PPI can improve the eradication rate of Hp, reduce the incidence of adverse drug reactions, reduce serum G17, and improve PG levels.