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肠道微生物、表观遗传修饰与肿瘤防治的研究进展

Advanced research of intestinal microbes and epigenetic modification,and tumor prevention and treatment
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摘要 肠道微生物是人体最庞大、最复杂的微生态系统,在调节人体健康方面发挥着重要作用。肠道微生物可以调控相关信号通路及表观遗传修饰,进而在促进或抑制多种肿瘤的生长、扩散和转移中发挥重要作用。本文以肠道微生物为出发点,综述了粪菌移植和益生菌2种直接调控肠道微生物的方式,以及肠道微生物对表观遗传修饰的影响,为肿瘤防治提供新的策略。 Intestinal microbes are the largest and most complex micro-ecological system in the human body and play an important role in regulating human health.Intestinal microbes can regulate related signaling pathways and epigenetic modifications,and accordingly promote or inhibit the growth,expansion and metastasis of various tumor.This article focuses on intestinal microbes,reviews 2 ways of directly regulating intestinal microbes(fecal microbiota transplantation and probiotics),and investigates the influence of intestinal microbes on epigenetic modification,thus providing new strategies for tumor prevention and treatment.
作者 何楠 麻婧 钱美睿 吴开春 HE Nan;MA Jing;QIAN Mei-rui;WU Kai-chun(State Key Laboratory of Cancer Biology,Xijing Hospital of Digestive Diseases,Air Force Military Medical University,Xi’an 710043,China)
机构地区 空军军医大学西京消化病医院肿瘤生物学国家重点实验室 空军军医大学西京消化病医院消化内科
出处 《传染病信息》 2019年第4期304-306,311,共4页 Infectious Disease Information
基金 国家自然科学基金创新群体项目(81421003)
关键词 肠道微生物 表观遗传修饰 肿瘤 intestinal microbes epigenetic modification tumor
分类号 R37 [医药卫生—病原生物学] R730.1 [医药卫生—肿瘤]
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