肝水解肽不良反应文献分析

Document analysis of adverse reactions of Heparolysate Injection

目的:探索注射用肝水解肽不良反应发生特点,为临床用药提供参考。方法:通过在医药期刊数据库上检索“肝水解肽”合并“致”、“副作用”、“不良反应”等关键词,共收集肝水解肽不良反应相关文章27篇,并整理分析。结果:肝水解肽不良反应的发生与性别无关,与年龄无关。不良反应的主要类型是免疫系统损害34例(35.42%),其次是呼吸系统20例(20.83%)、心血管系统15例(15.63%)和皮肤及附件系统损害11例(11.46%)以及消化系统9例(9.38%),神经系统7例(7.28%)。结论:免疫系统反应是肝水解肽最常见的不良反应,本案例中的肝水解肽基本上是用于肿瘤患者化疗时的保肝护肝治疗,患者免疫功能下降和超说明书用药会增加肝水解肽不良反应发生率,在使用中要谨慎。

Objective:To establish quality control of Jinguo Yin.Methods:TLC method was used to differentiate scrophulariae radix,terminalia chebula retz.and citri pericarpium reticulatae. HPLC method was used to determine content of hesperidin.C18 column(4.6mm×250mm,5μm)was used with methanol and 6% acetic acid (35∶65) as a mobile phase.The flow rate was 1mL·min-1,detection wavelength was 283 nm. Results:Samples and controls had the same color fluorescence spots at the same position in the TLC method.Spots were well isolated.In the HPLC method, linear range was 36.35~726.95ng(r =0.9999, n=5).Average recovery was 98.58%(RSD=1.85%,n=9).Conclusion:The established method was sensitive,accurate,repeatable and specific.It can be used for quality control of Jinguo Yin.