药源性严重过敏反应在临床上的分析

Clinical Analysis of drug-induced severe allergic reaction

目的了解药源性严重过敏反应的发生情况及救治流程。方法对8例过敏性休克和严重过敏样反应的致敏药物、发生时间、临床症状、救治措施及临床结局等进行回顾性分析。结果8例药源性严重过敏反应病例,临床症状主要表现在皮肤黏膜,呼吸系统、心血管系统和神经系统。抢救过程中,应用肾上腺素4例,包括静脉注射3例,皮下注射1例;痊愈6例,仍在住院治疗2例,无死亡病例。结论为预防和减少严重过敏反应的伤害,建立规范、有效的预防及抢救措施具有重要意义。

Objective To study the occurrence and treatment process of drug-induced severe allergic reaction. Methods Eight patients with anaphylactic shock and severe anaphylaxis underwent retrospective analysis, including the sensitizing drugs, time of occurrence, clinical symptoms, treatment measures and clinical outcomes. Results The symptoms of 8 patients with drug-induced severe allergic reactions were mainly shown in skin and mucosa, respiratory system, cardiovascular system and nervous system. In the course of rescue, 4 patients were treated with epinephrine, including 3 patients with intravenous injection and 1 patient with subcutaneous injection. Six patients recovered, 2 patients were still hospitalized, and no death occurred. Conclusion To prevent and reduce the injury of severe allergic reaction, the establishment of standard and effective prevention and rescue measures is of great significance.