酒精依赖患者与非饮酒健康人群生化指标的比较

Comparison of biochemical indicators between alcohol dependent patients and non-drinking healthy people

目的比较酒精依赖患者与非饮酒健康人群生化指标的差异。方法选取酒精依赖患者500例设为酒精依赖组,非饮酒健康人群500例设为对照组,检测2组血清丙氨酸氨基转移酶(ALT)、血清天门冬氨酸氨基转移酶(AST)、血清γ-谷氨酰基转移酶(γ-GT)、总胆汁酸(TBA)、超敏C-反应蛋白(hs-CRP)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、血清尿酸(UA)、血糖(GLU)、血清肌酐(Cr)、血清尿素氮(BUN),进行统计学分析。结果酒精依赖组血清ALT、AST、γ-GT、TBA、hs-CRP、HDL-C、TG、UA、GLU均显著高于对照组,差异有统计学意义(P<0.01)。酒精依赖组LDL-C水平与对照组相比,差异无统计学意义(P>0.05),Cr和BUN水平与对照组相比,差异无统计学意义(P>0.05);酒精依赖组γ-GT与TBA、UA与CR、TG与CR均呈正相关关系,HDL-C与TG、HDL-C与LDL-C呈负相关关系。结论饮酒可对肝细胞造成损害,同时使机体糖代谢和脂类代谢发生紊乱,严重危害身心健康。

Objective To compare the differences of biochemical indexes between patients with alcohol dependence and those with non-drinking health. Methods 500 cases of patients with alcohol dependenee were selected as the alcohol dependence group, and 500 healthy people without drinking were selected as the control group. ALT, AST,γ-GT, TBA , hs-CRP, HDL-C, LDL-C, TG, UA, GLU, Cr, BUN were detected and statistically analyzed. Results Serum levels of ALT, AST,γ-GT, TBA, hs-CRP, HDL-C, TG, UA and GLU in the alcohol dependent group were significantly higher than those in the control group, with the differences statistically significant ( P <0.01). LDL-C levels were higher in the alcohol dependent group than that in the control group, but the difference was not statistically significant ( P〉0.05). Cr and BUN levels were slightly lower than those in the control group and there was no statistical significance on the difference ( P >0.05). As for the alcohol dependence group, there was a significant positive correlation between γ-GT and TBA , UA and CR, TG and CR. There was a negative correlation between HDL-C and TG, HDL-C and LDL-C. Conclusion Drinking alcohol can cause damage to liver cells, and lead to the body's glucose metabolism and lipid metabolism disorder, causing serious harm to physical and mental health.