慢性肾脏病患者RBP与T淋巴细胞亚群检测的临床意义

Clinical Significance of Detection of RBP and T Lymphocyte Subsets in Patients with Chronic Kidney Disease

目的探讨慢性肾脏病(CKD)不同分期患者视黄醇结合蛋白(RBP)与T淋巴细胞亚群检测的临床意义。方法选取2017年1月~2018年11月收治于应城市人民医院肾内科住院356例CKD患者设为CKD组,另选同期55例健康体检者设为对照组,其中CKD组根据肾小球滤过率水平分为五期,根据五期分为相应五组,依次分为CKD1组、CKD2组、CKD3组、CKD4组、CKD5组,五组病情逐渐加重,检测其外周血CD3^+、CD4^+、CD8^+T淋巴细胞绝对数与RBP、Cr、UA、β2-MG并比较。结果CKD组患者CD3^+、CD4^+低于对照组,差异有统计学意义(P<0.05);两组CD8+比较,差异无统计学意义(P>0.05);CKD各期CD3^+、CD4^+、CD8^+计数比较,差异有统计学意义(P<0.05);CKD组Cr、β2-MG分别低于对照组,RBP、UA分别高于对照组,差异有统计学意义(P<0.05);RBP与CD3^+、CD4^+、CD8^+均呈正相关(P<0.05);Cr与CD3^+、CD4^+、CD8^+均呈负相关(P<0.05);UA与CD3^+、CD4^+、CD8^+均呈正相关(P<0.05)。结论从CKD1期发展至CKD5期过程中,患者血清RBP逐渐降低,细胞免疫功能下降,且与CKD分期密切相关。

Objective To investigate the clinical significance of detection of retinol binding protein(RBP)and T lymphocyte subsets in patients with different stages of chronic kidney disease(CKD).Methods From January 2017 to November 2018,356 patients with CKD admitted to the Department of Nephrology,Yingcheng People's Hospital were enrolled in the CKD group.Another 55 healthy subjects were selected as the control group.The CKD group was based on glomerular filtration.The over-rate level was divided into five stages.According to the five stages,it was divided into five groups,which were divided into CKD1 group,CKD2 group,CKD3 group,CKD4 group and CKD5 group.The five groups gradually became more serious,and their peripheral blood CD3^+,CD4^+,CD8^+T the absolute number oflymphocytes was compared with RBP,Cr,UA,andβ2-MG.Results The CD3^+and CD4^+levels in the CKD group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in CD8^+between the two groups(P>0.05).The differences of CD3^+,CD4^+and CD8^+counts in CKD were statistically significant(P<0.05).CKD The levels of Cr andβ2-MG were lower than those of the control group,and the RBP and UA were higher than the control group,the difference was statistically significant(P<0.05).The RBP was positively correlated with CD3^+,CD4^+and CD8^+(P<0.05).There was a significant negative correlation between Cr and CD3^+,CD4^+and CD8^+(P<0.05).There was a significant positive correlation between UA and CD3^+,CD4^+and CD8^+(P<0.05).Conclusion During the progression from CKD1 to CKD5,serum RBP is gradually decreased,cellular immune function is decreased,and it is closely related to CKD stage.