右美托咪定对腹腔镜胆囊切除术患者血清IL-10和TNF-α的影响

Effect of Dexmedetomidine on Serum IL-10 and TNF-α in Patients Undergoing Laparoscopic Cholecystectomy

目的探讨右美托咪定对腹腔镜胆囊切除术患者血清IL-10和TNF-α的影响。方法选取2017年6月~2018年12月我院收治的行腹腔镜胆囊切除术患者64例,采用随机数字表法分为对照组和观察组,每组32例。两组患者均行全麻联合硬膜外麻醉,观察组静脉泵注右美托咪定,对照组给予生理盐水,比较两组麻醉前后血清IL-10和TNF-α水平及不良反应发生情况。结果麻醉后,两组血清IL-10、TNF-α水平高于麻醉前,差异有统计学意义(P<0.05);观察组IL-10水平高于对照组[(71.04±11.25)ng/mlvs(54.37±9.13)ng/ml],TNF-α水平低于对照组[(1.54±0.23)ng/mlvs(2.18±0.36)ng/ml],差异有统计学意义(P<0.05)。观察组不良反应发生率为15.62%,低于对照组的40.63%,差异有统计学意义(P<0.05)。结论右美托咪啶应用于腹腔镜胆囊切除术中能缓解炎症反应,减少不良反应的发生。

Objective To investigate the effects of dexmedetomidine on serum IL-10 and TNF-αin patients undergoing laparoscopic cholecystectomy.Methods 64 patients undergoing laparoscopic cholecystectomy admitted to our hospital from June 2017 to December 2018 were randomly divided into the control group and the observation group,with 32 cases in each group.Both groups underwent general anesthesia combined with epidural anesthesia.The observation group received dexmedetomidine intravenously,and the control group received normal saline.The levels of serum IL-10 and TNF-αand adverse reactions were compared before and after anesthesia.Results After anesthesia,the levels of serum IL-10 and TNF-αin the two groups were higher than those before anesthesia,the difference was statistically significant(P<0.05);the IL-10 level in the observation group was higher than that in the control group[(71.04±11.25)ng/ml vs(54.37±9.13)ng/ml],and the TNF-αlevel was lower than the control group[(1.54±0.23)ng/ml vs(2.18±0.36)ng/ml],the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 15.62%,which was lower than that in the control group 40.63%,the difference was statistically significant(P<0.05).Conclusion Dexmedetomidine can alleviate the inflammatory response and reduce the incidence of adverse reactions in laparoscopic cholecystectomy.