兰索拉唑联合多潘立酮治疗反流性食管炎疗效

Evaluation of the Efficacy of Lansoprazole Combined With Domperidone in the Treatment of Patients With Reflux Esophagitis

目的关于对兰索拉唑与多潘立酮联合治疗反流性食管炎患者的临床疗效进行研究探讨。方法数字表法将2017年2月-2018年5月来我院治疗反流性食管炎的患者随机选取120例(以上患者均经过胃镜检查以及组织病理学检查证实为反流性食管炎),将以上患者分为两组,其中对照组60例,观察组60例;对照组60例予奥美拉唑治疗,观察组60例给予兰索拉唑联合多潘立酮治疗,治疗观察3周后对比了两组的治疗效果。结果对照组总有效率为(76.65%)低于观察组的总有效率(93.32%),差异具有统计学意义(P<0.05);两组患者的临床症状分级评分,在治疗前,两组患者症状比较差异不具有统计学意义(P>0.05),经治疗后,观察组的临床症状分级评分优于对照组,差异有统计学意义(P<0.05)。结论反流性食管炎患者经兰索拉唑联合多潘立酮的治疗后临床症状得到了改善,效果显著。

Objective To investigate the clinical efficacy of lansoprazole combined with domperidone in the treatment of patients with reflux esophagitis.Methods The digital table method will be randomly selected from 120 patients who have come to our hospital for treatment of reflux esophagitis from February 2017 to May 2018(The above patients were confirmed by gastroscopy and histopathological examination for reflux esophagitis).The above patients were divided into two groups:60 cases in the control group and 60 cases in the observation group;60 cases in the control group were treated with omeprazole,and 60 cases in the observation group were treated with lansoprazole combined with domperidone.After 3 weeks of treatment,the comparison was compared.The therapeutic effect of the two groups.Results The total effective rate of the control group(76.65%)was lower than the total effective rate of the observation group(93.32%),and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the clinical symptom grading score between the two groups(P>0.05).After treatment,the clinical symptom grading score of the observation group was significantly better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical symptoms of lansoprazole combined with domperidone have been significantly improved in patients with reflux esophagitis.The effect is significant.