糖皮质激素治疗非特异性间质性肺炎的效果

The Effect of Glucocorticoid on Non-specific Interstitial Pneumonia

目的观察糖皮质激素治疗非特异性间质性肺炎的临床疗效。方法将2018年1月-2019年4月于本院治疗的43例非特异性间质性肺炎患者纳入本次研究,根据治疗差异将其分为观察组(n=22)和对照组(n=21),对照组展开常规治疗,观察组实施糖皮质激素治疗。而后对比两组患者肺功能情况、血气指标情况、临床症状改善情况、炎症指标缓解情况以及治疗效果。结果观察组FEV1、FVC、PaO2、SaO2、体温恢复时间、肺部湿罗音消失时间、肺部CT好转时间、C-反应蛋白、中性粒细胞以及血沉与对照组比较差异具有统计学意义,P<0.05;观察组总有效率为95.45%优于对照组66.67%差异具有统计学意义,P<0.05。结论糖皮质激素治疗非特异性间质性肺炎的临床疗效显著。

Objective To observe the clinical efficacy of glucocorticoids in the treatment of non-specific interstitial pneumonia.Methods From January 2018 to April 2019.43 patients with non-specific interstitial pneumonia who were treated in our hospital were included in the study.They were divided into observation groups according to treatment differences(n=22).The control group(n=21),the control group underwent routine treatment,and the observation group received glucocorticoid therapy.Then compare the lung function,blood gas index,clinical symptom improvement,inflammation index relief and treatment effect in the two groups.Results The observation group FEV1,FVC,PaO2,SaO2,body temperature recovery time,lung wet rales disappearing time,lung CT improvement time,C-reactive protein,neutrophils and erythrocyte sedimentation rate were significantly different from the control group,P<0.05;The total effective rate of the observation group was 95.45%,which was significantly higher than that of the control group(66.67%),P<0.05.Conclusion The clinical efficacy of glucocorticoids in the treatment of non-specific interstitial pneumonia is significant.