丁苯酞序贯治疗脑小血管病认知障碍疗效观察

Therapeutic Effect of Sequential Butylphthalide on Cognitive Impairment in Patients With Cerebrovascular Disease

目的探讨脑小血管病认知障碍患者实施丁苯酞序贯治疗的效果。方法将神经内科80例脑小血管病认知障碍患者(2017年1月-2019年1月)纳入研究,用计算机随机分组:尼莫地平组(n=40,基础治疗+尼莫地平)和丁苯酞组(n=40,基础治疗+丁苯酞序贯治疗),分析效果。结果丁苯酞组治疗后蒙特利尔认知量表评分、简易精神状态量表评分与尼莫地平组组间对比更高,血清同型半胱氨酸、血清反应蛋白水平与尼莫地平组组间对比更低(P<0.05)。丁苯酞组用药不良反应发生率与尼莫地平组对比差异无统计学意义(P>0.05)。结论脑小血管病认知障碍患者实施丁苯酞序贯治疗可改善认知功能及炎症状况。

Objective To investigate the effect of sequential butylphthalide therapy on cognitive impairment of cerebrovascular disease.Methods 80 patients with cognitive impairment of cerebrovascular disease in neurology department(from January 2017 to January 2019)were enrolled in the study.They were randomly divided into nimodipine group(n=40,basic therapy+nimodipine)and butylphthalide group(n=40,basic therapy+sequential treatment of butylphthalide).Results After treatment,the montreal cognitive scale score and simple mental state scale score in the butylphthalide group were higher than those in the nimodipine group,and the levels of serum homocysteine and serum reactive protein were lower than those in the nimodipine group(P<0.05).There was no significant difference in the incidence of adverse drug reactions between butylphthalide group and nimodipine group(P>0.05).Conclusion Sequential butylphthalide therapy can improve cognitive function and inflammation in patients with cognitive impairment of cerebrovascular disease.