摘要
异基因造血干细胞移植(allo-HSCT)是治愈多种非恶性病的有效方法。脐带血干细胞(UCB)具有免疫原性低、人类白细胞抗原不合耐受性好、移植物抗宿主反应发生率低以及获取相对快捷等特点,可作为非恶性血液疾病患者allo-HSCT的来源。本文简要综述脐血干细胞移植在原发性免疫缺陷病、遗传性骨髓衰竭、遗传代谢病以及自身免疫性疾病等非恶性血液疾病的治疗效果。
Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an effective method to cure non-malignant hematological diseases.Umbilical cord blood stem cells(UCB)are characterized by weak immunogenicity,good tolerance human leukocyte antigen(HLA)mismatch,low incidence of graft-versus-host disease and relatively fast availability.UCB can be used as the graft of allo-HSCT for patients with non-malignant hematological diseases.This article reviews the efficacy of the umbilical cord blood stem cell transplantation(UCBT)in patients with primary immunodeficiency,hereditary bone marrow failure,hereditary metabolic diseases and autoimmune diseases.
作者
王苹
翟晓文
Wang Ping;Zhai Xiaowen(Department of Hematology/oncology,Children's Hospital of Fudan University,Shanghai 201102,China)
出处
《中华细胞与干细胞杂志（电子版）》
2019年第4期242-246,共5页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
关键词
脐带血
造血干细胞
移植
非恶性疾病
Umbilical cord blood
Stem cells
Transplantation
Non-malignant diseases
