摘要
阿尔兹海默症(AD)是一种病理机制复杂,以进行性认知功能障碍为主的中枢神经系统疾病,目前仍缺乏有效的治疗方法。多项研究结果显示,间充质干细胞(MSCs)外泌体能够促进抗炎、调节免疫功能、加强Aβ降解、促进神经细胞轴突生长等,能很好地针对AD的核心病理机制发挥效果从而达到治疗效果。本文主要介绍MSCs外泌体在各项AD病理机制治疗中的研究进展。
Alzheimer's disease(AD)is a kind of central nervous system disease with complex pathological mechanism and progressive cognitive dysfunction.Currently,there is still a lack of effective treatment.Some research results showed that mesenchymal stem cell exosomes could exert therapeutic effects on AD by promoting anti-inflammatory,regulating immune function,enhancing Aβdegradation,and promoting axonal growth of neurons.This article mainly introduces the research progress of mesenchymal stem cell exosomes in the treatment of Alzheimer's disease.
作者
金圣榆(综述)
葛丽特(综述)
卢明(审校)
Jin Shengyu;Ge Lite;Lu ming(Hunan Key Laboratory of Neurorestoratology,Department of Neurosurgery,the Second Affiliated Hospital( the 921st Hospital of PLA),Hunan Normal University,Changsha 410003,China;the National & Local Joint Engineering Laboratory of Animal Peptide Drug Development,College of Life Sciences,Hunan Normal University,Changsha 410006,China)
出处
《中华细胞与干细胞杂志（电子版）》
2019年第4期247-250,共4页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
湖南省教育厅研究生科研创新项目(CX2018B309,CXCX2018B240)
关键词
阿尔兹海默症
间充质干细胞
外泌体
免疫调节
Alzheimer's disease
Mesenchymal stem cells
Exosomes
Immune regulation
