系统性红斑狼疮患者发生静脉血栓栓塞事件的风险

Risk of venous thromboembolism in patients with systemic lupus erythematosus

系统性红斑狼疮患者发生静脉血栓(venous thromboembolism,VTE)事件,包括肺栓塞(pulmonary embolism,PE)和深静脉血栓(deep vein thrombosis,DVT)的风险显著增加。其病因及发病机制相当复杂,除原发病疾病活动因素外,还涉及抗磷脂抗体、低白蛋白血症、高球蛋白血症、长期应用糖皮质激素所导致的糖、脂代谢异常、肥胖等。至今,国内外文献尚未针对SLE患者发生VTE的危险因素进行全面系统性分析,本文将对SLE发生静脉血栓栓塞事件的相关研究进展做一综述。

The risk of venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is significantly increased in patients with systemic lupus erythematosus. Its etiology and pathogenesis are quite complicated, involved with the disease activities, antiphospholipid antibodies, hypoproteinemia, hyperglobulinemia and glyeolipid metabolism disorders caused by long-term application of glucocorticoids. The risk factors of VTE in lupus patients were hardly analyzed before in literatures. The progress in research of VTE events in lupus patients was reviewed in this article.