鹿瓜多肽联合双醋瑞因治疗膝骨关节炎的疗效

Effect of cervus and cucumis polypeptide combined with diacerein in the treatment of knee osteoarthritis

目的探讨鹿瓜多肽联合双醋瑞因治疗膝骨关节炎的疗效。方法选取2015年1月至2016年6月在九江市第一人民医院门诊及住院治疗的90例膝骨关节炎患者作为研究对象。利用分层随机方法分为双醋瑞因组、鹿瓜多肽组及联合组,每组30例。疗程均为4周。比较3组治疗前后的关节炎指数量表评分(WOMAC)、视觉模拟评分(VAS)、关节压痛度,并评估治疗效果及治疗期间的不良反应。结果治疗4周后,3组WOMAC评分、VAS评分及关节压痛度均较治疗前显著改善(均P<0.01),且联合组的治疗效果明显优于双醋瑞因组和鹿瓜多肽组(均P<0.05)。联合组不良反应发生率与双醋瑞因组和鹿瓜多肽组比较差异均无统计学意义(均P>0.05)。结论鹿瓜多肽联合双醋瑞因治疗膝骨关节炎的疗效明显优于单一用药,且不会加重不良反应。

Objective To investigate the effect of cervus and cucumis polypeptide combined diacerein in the treatment of knee osteoarthritis. Methods From January 2015 to June 2016, 90 patients with previous diagnosis of knee osteoarthritis were randomly divided into combined group, diacerein group and cervus and cucumis polypeptide group in Department of Orthopaedics, Jiujiang First People's Hospital. Thirty patients were in each group, raceivied a treatment course of 4 weeks. The therapeutic efficacy, arthritis index scale score (WOMAC), visual analogue scale (VAS), joint tenderness were compared among the 3 groups, and therapeutic effect and adverse reactions during treatment were evaluated. Results After 4 weeks of treatment, the WOMAC score, VAS score, joint tenderness of 3 groups were improved significantly compared with those before treatment (all P <0.01), the improvement of therapeutic effect in combined group was better than that of diacerein group and cervus and cucumis polypeptide group ( P <0.05). The adverse reactions in 3 groups had no significant difference (all P >0.05). Conclusion The effect of cervus and cucumis polypeptide combined with diacerein in the treatment of knee osteoarthritis is obviously superior to that of the single treatment, and does not aggravate adverse reactions.