肠道菌群与炎症性肠病的研究进展

Research Progress in Intestinal Flora and Inflammatory Bowel Disease

炎症性肠病(IBD)被认为是一种非特异性的慢性复发性肠道炎症疾病,多认为是由遗传因素、环境因素、肠道菌群和宿主免疫系统等的复杂相互作用导致的异常免疫反应和慢性肠道炎症,但确切病因和发病机制尚未完全阐明。正常肠道微生物群可形成生物屏障,起到促消化、营养吸收、免疫、抗肿瘤以及代谢等作用,对宿主的健康有益。新一代测序技术的最新进展已经确定了IBD中肠道微生物群的组成和功能的改变,这些改变可能与IBD发生有关。因此,探索和运用血清学微生物标志诊断IBD成为可能,也为IBD治疗方案提供了全新方法。

Inflammatory bowel disease(IBD) is considered as a non-specific chronic recurrent intestinal inflammatory disease.It is believed that the complex interaction of genetic factors,environmental factors,intestinal flora and host immune system leads to abnormal immune response and chronic intestinal inflammation,however,the exact etiology and pathogenesis of IBD have not yet been fully elucidated.Normal intestinal microflora can form a biological barrier,which can promote digestion ,nutrient absorption,immunity,anti-tumor and metabolism,and is beneficial to the health of the host.Recent advances in new generation sequencing technology have identified changes in the composition and function of intestinal microflora in IBD,which may be related to the occurrence of IBD. Therefore,it is possible to explore and apply serological microbial markers in the diagnosis of IBD and provide a new method for the treatment of IBD.