HPV16基因组甲基化对宫颈病变的影响

Effects of HPV16 Genomic Methylation on Cervical Lesions

人乳头瘤病毒(HPV)导致的生殖道感染是宫颈癌及癌前病变的主要诱因。高致病性HPV16亚型感染可增加宫颈癌的患病风险,但多为自限性感染,仅部分患者发生宫颈癌变,故仍需对HPV携带者的癌变风险进行精确的检测和判断。HPVDNA甲基化与癌症发生发展密切相关,HPVDNA甲基化与病毒载量、复制转录以及病毒致瘤性具有相关性。准确鉴定HPV相关的甲基化模式对宫颈上皮内瘤变具有较好的诊断价值,将有助于改善宫颈癌癌前病变患者的筛查、临床诊断及治疗。

Reproductive tract infection caused by human papillomavirus(HPV) is the main cause of cervical cancer and precancerous lesions.Highly pathogenic HPV16 subtype infection can increase the risk of cervical cancer,but most of them are self-limiting infections.Cervical canceration occurs in only some patients,so it is still necessary to accurately detect and judge the carcinogenesis risk of HPV carriers.HPV DNA methylation is closely related to the occurrence and development of cancer,and HPV DNA methylation is correlated to viral load,replication and transcription,and viral tumorigenicity.Accurate identification of HPV-related methylation patterns has a good diagnostic value for cervical intraepithelial neoplasia,which will help to improve the screening,clinical diagnosis and treatment of cervical precancerous lesions.