肝脏手术围手术期血液保护进展

Strategies of Perioperative Blood Conservation in Liver Surgery

目前肝脏外科手术仍是治疗多种肝病(如肿瘤性疾病、先天性疾病等)的有效手段,但手术时术中出血和输血仍时有发生,这主要是因为肝脏是一个高度血管化的器官,并且能够合成绝大部分的凝血因子,外科手术时损伤肝脏,从而导致出血和失血。肝脏手术围术期血液保护具有非常重要的作用,深入研究围术期血液保护过程中的循环干预、自体输血以及药物处理等有助于降低异体输血率,提高患者对肝脏手术和失血的耐受性,改善预后,提高患者的生存率。

At present,liver surgery is still an effective means to treat a variety of liver diseases(such as tumor diseases,congenital diseases).However,bleeding and blood transfusions still occur during surgery,mainly because the liver is a highly vascularized organ and synthesizes most of the clotting factors.When liver is damaged during surgery,it results in bleeding and blood loss.The strategy of perioperative blood conservation during liver surgery is very important.Further study of perioperative circulatory intervention,autotransfusion and drug treatment ofliver surgery can help to improve the patients′ tolerance to liver surgery and blood loss,improving the prognosis and survival rate.