肠道微生物在类风湿关节炎发病机制中的研究进展

Progress in Study of Intestinal Microorganism in Pathogenesis of Rheumatoid Arthritis

类风湿关节炎(RA)是一种常见的全身性自身免疫性疾病,主要以对称性小关节病变为主,常累及多关节,导致关节畸形和功能丧失,严重影响患者的生活质量。遗传和环境因素参与类风湿关节炎的发病,且与免疫功能紊乱相关,但具体机制目前尚不清楚。肠道是人体最大的免疫器官,同时也是人体最大的微生态环境,肠道菌群参与机体的免疫调节,与人体的免疫功能密切相关,对肠-关节轴的相关研究可能成为了解RA发病机制的新视角。

Rheumatoid arthritis(RA)is a common systemic autoimmune disease,mainly symmetrical facet joint disease,often involving multiple joints,leading to joint deformity and functional loss,seriously affecting the quality of life of the patients.Genetic and environmental factors are involved in the pathogenesis of RA,which is also related to immune dysfunction,but the specific mechanism is still unclear.Intestinal tract is not only the largest immune organ,but also the largest micro-ecological environment of the human body.Intestinal flora is involved in the immune regulation of the body,closely related to the immune function of the human body.The study of intestinal-articular axis may become a new perspective to understand the pathogenesis of RA.