Toll样受体4与肺纤维化相关的研究进展

Research Progress of Toll-like Receptor 4 and Pulmonary Fibrosis

肺纤维化是一种病因复杂的间质性肺病,目前尚无有效治疗方法。而Toll样受体4(TLR4)作为免疫家族的重要膜识别受体,与多种纤维性疾病有密切关系。TLR4与相关配体结合后可激活下游一系列靶蛋白或诱导自噬相关信号通路的激活,介导各种炎症细胞因子的产生,参与肺纤维化的发生发展。由于TLR4信号通路复杂,对肺纤维化的影响来源于多个方面,所以其在肺纤维化发展过程中的作用机制尚不明确。未来通过干预TLR4信号通路的关键靶点,探索其在肺纤维化发展过程中的具体作用,将为治疗肺纤维化提供新思路。

Pulmonary fibrosis is a kind of interstitial lung disease with complicated pathogenesis and has no effective treatment at present.Toll-like receptor 4(TLR4)as an important membrane recognition receptor of the immune family,is closely related to various fibrous diseases.TLR4 binding with related ligands can activate a series of downstream target proteins or induce the activation of autophagy-related signaling pathways,and mediate the production of various inflammatory cytokines to participate in the occurrence and development of pulmonary fibrosis.Because of the complexity of TLR4 signaling pathway and the multi-aspect effect of TLR4 on pulmonary fibrosis,so its mechanism in the development of pulmonary fibrosis is still unclear.In the future,it will provide new ideas for the treatment of pulmonary fibrosis by intervening key targets of TLR4 signaling pathway and exploring its specific role in the development of pulmonary fibrosis.