自噬介导幽门螺杆菌感染相关胃癌信号通路的研究进展

Research Progress in Autophagy-mediated Signaling Pathway of Helicobacter Pylori Infection associated Gastric Cancer

幽门螺杆菌(Hp)感染引起的炎症是导致胃癌发生发展的高风险因素之一,其发病的分子机制尚不明确,可能与Hp感染诱发细胞形成自噬小体介导下游宿主细胞的信号转导密切相关。目前,现代细胞分子生物学发展迅猛,细胞信号通路(Wnt/β联蛋白通路、磷脂酰肌醇-3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白通路、核因子κB通路、转化生长因子-β通路及微RNAs相关信号通路等)已成为胃癌发病分子机制及靶向治疗的研究热点。因此,自噬介导Hp感染相关GC信号通路的研究将成为发展趋势,其研究结果将为胃癌治疗提供新方向。

The inflammation caused by Helicobacter pylori(Hp)infection is one of the high risk factors for the occurrence and development of gastric cancer.The molecular mechanism of the pathogenesis is not clear,which may be closely related to the signal transduction of downstream host cells mediated by autophagosome induced by Hp.At present,with the rapid development of modern cellular and molecular biology,cellular signaling pathways such as Wnt/β-catenin pathway,phosphatidylinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathway,nuclear factor-κB pathway,transforming growth factor-βpathway and microRNAs-related signaling pathway,have become the focus of research on the molecular mechanism and targeted therapy of gastric cancer.Therefore,the study of autophagy-mediated Hp-related gastric cancer signaling pathway will become a development trend,and the research results will provide a new direction for the treatment of gastric cancer.