基于《王仲奇医案》探析王仲奇辨治泄泻的处方用药规律

Analysis on the Law of Prescription and Drug use of Wang Zhongqi in differentiation and treatment of Diarrhea based on “Wang Zhongqi Medical case”

目的:探究《王仲奇医案·泄泻》中治疗泄泻的用药配伍特色。方法:从《王仲奇医案》中选取泄泻病案,提取方药信息,用office2010建立数据库整理归纳数据,进行频数分析,运用SPSS22.0对用药情况进行相关数据挖掘分析,阐述王氏辨治泄泻经验,综合分析其辨治方药规律特色。结果:其中用药频次最高的五味药物分别是:茯苓、白术、佩兰、肉豆蔻、益智仁。性味归经方面,药味以甘、苦、辛为主;药性以温、寒、平居多,归经以脾、胃、肝、肺经为主。药类频数分析反映补虚药、收涩药、利水渗湿药、化湿药、理气药为最常用的药物类别。聚类结果分析包括:C1:枳壳、大腹皮;C2:防风、禹余粮、罂粟壳;C3:白芍、益智仁;C4:神曲、大麦;C5:石斛、化橘红;C6:枳壳、大腹皮、陈皮、白豆蔻、半夏;C7:蒲公英、鸡内金;C8:白术、肉豆蔻、茯苓;C9:佩兰。结论:《王仲奇医案》所载泄泻以肝郁脾虚、脾胃虚弱及脾肾阳虚证为主;数据挖掘分析王仲奇治疗泄泻用药规律的总结具有重要的临床意义,在临床实践中有一定的借鉴价值。

Objective To explore the characteristics of drug compatibility in the treatment of diarrhea in the case of Wang Zhongqi. Methods The diarrhea case was selected from Wang Zhongqi Medical case, the information of prescription and medicine was extracted, the data was collected by office 2010 database, the frequency was analyzed, and the related data were mined and analyzed by SPSS 22.0. This paper expounds Wang’s experience in distinguishing and treating diarrhea, and comprehensively analyzes the characteristics of the law of differentiation and treatment of prescriptions and medicines. Results The five most frequently used drugs were: Poria cocos, Atractylodes macrocephala, Perrin, nutmeg and Izhiren. The medicinal flavor is mainly sweet, bitter, and Xin, and the medicine is warm,cold and flat that was the majority, the main meridian was spleen, stomach, liver and lung. The analysis of the frequency of drugs shows that the most commonly used drugs are tonifying drugs, astringent drugs, moisturizing drugs, dehumidifying drugs and regulating qi drugs. Cluster analysis included: C1: Fructus aurantii, large abdominal peel;C2: Fangfeng, Yu surplus grain, poppy shell;C3: Radix Paeoniae Alba, Yizhiren;C4: Shenqu, Barley;C5: Dendrobium, red orange;C6: Fructus aurantii, large abdominal peel, old peel, white nutmeg, Pinellia ternata;C7: dandelion, chicken gold;C8: Atractylodes macrocephala, nutmeg, Poria cocos;C9: Perrin. Conclusion The diarrhea contained in "Wang Zhongqi Medical case" is characterized by liver stagnation and spleen deficiency, spleen and stomach weakness and deficiency of spleen and kidney yang. Mainly. Data mining analysis of Wang Zhongqi treatment of diarrhea drug use law summary has important clinical significance, in clinical practice has certain reference value.