摘要
以聚乙二醇(Polyethylene glycol,PEG)为溶剂及反应剂,聚乙烯亚胺(Polyethyleneimine,PEI)为添加剂,乙酰丙酮铁(Fe(acac) 3 )为铁源,采用高温热分解法制备了超顺磁性氧化铁纳米粒子(Super-paramagnetic iron oxide nanoparticles,SPIONs)。通过物理法将聚天冬氨酸(Poly aspartic acid,PASP)成功修饰在PEG、PEI修饰的超顺磁性氧化铁纳米粒子(PEG/PEI-SPIONs)表面,得到PEG/PEI/PASP-SPIONs。透射电子显微镜表征结果显示,PEG/PEI/PASP-SPIONs具有良好的分散性,且平均粒径为(10.8±2.0) nm(平均值±标准差)。小鼠脑部磁共振成像实验表明,PEG/PEI/PASP-SPIONs可以长时间在小鼠脑部呈现磁共振成像(MRI)效果,PEG/PEI/PASP-SPIONs在小鼠脑部的成像时间比PEG/PEI-SPIONs和PEG/PEI/Tween 80-SPIONs的成像时间更短,可用于磁共振成像的造影剂。
Polyethylene glycol (PEG) was used as solvent and reagent, polyethyleneimine (PEI) was used as additive, iron (III) acetylacetonate (Fe(acac) 3 ) was used as iron source, and super-paramagnetic iron oxide nanoparticles (SPIONs) were prepared by high temperature thermal decomposition method. PEG/PEI/PASP-SPIONs were obtained by successfully modifying poly aspartic acid (PASP) on PEG and PEI coated SPIONs (PEG/PEI-SPIONs). Transmission electron microscopy (TEM) shows that PEG/PEI/ PASP-SPIONs have good dispersion and the average particle size was ( 10.8±2.0 )nm. Magnetic resonance imaging (MRI) of mouse brain show that PEG/PEI/PASP-SPIONs have MRI longer contrast effect in the brain of mice. The imaging time of PEG/PEI/PASP-SPIONs in the brain of mice was shorter than that of PEG/PEI-SPIONs and PEG/PEI/Tween 80-SPIONs. PEG/PEI/PASP-SPIONs can be used as MRI contrast agent.
作者
钟良
谢松伯
夏天
杨凤丹
聂婉
梁广钦
张宝林
ZHONG Liang;XIE Song-bo;XIA Tian;YANG Feng-dan;NIE Wan;LIANG Guang-qin;ZHANG Bao-lin(Guangxi Key Laboratory of Optoelectronic Materials and Devices,State Key Laboratory Breeding Base of Nonferrous Metals andSpecific Materials Processing,School of Materials Science and Engineering,Guilin University of Technology,Guilin 541004,China)
出处
《人工晶体学报》
EI
CAS
北大核心
2019年第8期1549-1556,共8页
Journal of Synthetic Crystals
基金
国家自然科学基金(51562007)
