肠道菌群与衰老相关疾病关系的研究进展

Research Progress on the Relationship between Aging and Its Related Diseases and Gut Microbiota

随着全球人口老龄化趋势的加剧,如何改善老年人口的生存质量成为一个全球性的公共卫生问题。肠道细菌作为人体最大的微生态系统,在衰老及相关疾病进程中起重要作用,日益受到临床医生关注。本文对肠道菌群与衰老相关疾病关系的国内外研究进展进行总结,并从影响老年人肠道菌群的因素、老年人肠道菌群变化的特点、肠道菌群代谢产物及其生理作用、肠道菌群代谢产物致病机制等方面进行综述,旨在为临床提供帮助。

With the increasing trend of global population aging,how to improve the quality of life of the elderly population becomes a global public health problem.As the largest micro-ecosystem of human body,intestinal bacteria play an important role in the process of aging and its related diseases,which has attracted more and more attention of clinicians.This paper summarizes the research progress of senility and intestinal flora at home and abroad,and reviews the factors affecting intestinal flora in the elderly,the characteristics of intestinal flora changes in the elderly,and the metabolites of intestinal flora and their physiological functions and the pathogenic mechanism in order to provide a reference for clinical practice.