摘要
目的探讨心型脂肪酸结合蛋白(H-FABP)与心肌酶谱诊断轮状病毒感染患儿心肌损伤的价值。方法选取该院轮状病毒感染患儿80例,于入组3~<6h、6~12h检测肌酸激酶(CK)、CK同工酶(CK-MB)、血清肌钙蛋白(cTnI)、天门冬氨酸氨基转移酶(AST)、血清乳酸脱氢酶(LDH)及H-FABP水平,比较心肌损伤与心肌正常患儿H-FABP、CK、CK-MB、cTnI、AST及LDH的水平及阳性率。结果3~<6h、6~12h轮状病毒感染心肌损伤患儿的H-FABP、CK、CK-MB、cTnI、AST及LDH水平显著高于心肌正常组患儿(P<0.05);轮状病毒感染心肌损伤患儿入组3~<6h、6~12h的H-FABP、CK-MB、cTnI阳性率显著高于心肌正常患儿(P<0.05);H-FABP在诊断轮状病毒感染患儿入组3~<6h、6~12h心肌损伤的约登指数均为最高,分别为83.02%、78.00%。结论H-FABP对轮状病毒感染患儿心肌损伤的诊断价值高于心肌酶谱。
Objective To explore the value of heart-type fatty acid binding protein(H-FABP)and myocardial zymogram in diagnosis of myocardial injury in children with rotavirus.Methods A total of 80 children with rotavirus infection in this hospital were selected.The levels of creatine kinase(CK),CK-MB,serum troponin(cTnI),aspartate aminotransferase(AST),lactate dehydrogenase(LDH)and H-FABP were measured at 3-<6 and 6-12 h after admission.The levels and positive rates of H-FABP,CK,CK-MB,cTnI,AST and LDH in patients with myocardial injury and normal myocardium were compared.Results The levels of H-FABP,CK,CK-MB,cTnI,AST and LDH in children with myocardial injury caused by rotavirus infection at 3-<6 h and 6-12 h were significantly higher than those in children with normal myocardium(P<0.05).The positive rates of H-FABP,CK-MB,and cTnI in children with myocardial injury caused by rotavirus infection for 3-<6 h and 6-12 h were significantly higher than those in children with normal myocardium(P<0.05).The Hadin index of H-FABP in diagnosing myocardial injury in children with rotavirus at 3-<6 h and 6-12 h was the highest,which was 83.02%and 78.00%respectively.Conclusion The diagnostic value of H-FABP for myocardial injury in children with rotavirus is higher than that of myocardial zymogram.
作者
林欢
陈灿锋
梁有卓
LIN Huan;CHEN Canfeng;LIANG Youzhuo(Department of Clinical Laboratory,Bao'an District Central Hospital,Shenzhen,Guangdong 518100,China)
出处
《检验医学与临床》
CAS
2019年第17期2455-2458,共4页
Laboratory Medicine and Clinic
基金
广东省深圳市宝安区社会公益项目(2015134)
关键词
心型脂肪酸结合蛋白
心肌酶谱
轮状病毒
heart-type fatty acid binding protein
myocardial enzymes
rotavirus