Th22和IL-22在呼吸道过敏性疾病发病机理中的作用被引量：6

The pathogenesis of Th22 and IL-22 in respiratory allergic diseases

导出

摘要 2009年首次提出了一种名为辅助性T细胞(helper T cell,Th)22的细胞亚群,该亚群以分泌白细胞介素(interleukin,IL)-22而得名.众多研究显示Th22细胞亦参与多种疾病的发生,目前研究认为Th22细胞在过敏性皮肤疾病中发挥促炎作用.然而,Th22细胞在哮喘和过敏性鼻炎中的作用尚存在争议.一部分研究人员认为Th22细胞具有促炎效应,而另一部分学者则认为Th22细胞具有抗炎作用.针对以上问题,现就近年来有关Th22细胞和IL-22在呼吸道过敏性疾病中的研究进展做一综述. A new population of T cells known as helper T cell (Th)22 was described for the first time in 2009. These cells are usually identified by the secretion of interleukin(IL)-22. More and more research indi-cate that Th22 cells are involved in the occurrence of a variety of diseases. Currently,it is believed that Th22 cells play a pro-inflammatory role in allergic skin diseases. However,the role of Th22 cells in asthma and aller-gic rhinitis is controversial. Some researchers suggest that Th22 cells have pro-inflammatory effects,while others believe that Th22 cells have anti-inflammatory effects. In view of the above problems,the role of Th22 cells and IL-22 in respiratory allergic diseases was reviewed in this paper.

作者高琦林庆国 Gao Qi;Lin Qingguo(Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, China;College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355 , China)

机构地区山东大学附属省立医院临床医学检验部山东中医药大学管理学院

出处《国际免疫学杂志》 CAS 2019年第5期516-519,共4页 International Journal of Immunology

基金国家自然科学基金(81801553) 山东省医药卫生科技发展计划(2017WS008).

关键词辅助性T细胞22 白细胞介素-22 过敏性鼻炎哮喘 Helper T cell 22 cell Interleukin -22 Allergic rhinitis Asthma

分类号 R593.1 [医药卫生—内科学]

引文网络
相关文献

参考文献2

1于伟,郑以州.Th22细胞在自身免疫性疾病中作用的研究进展[J].国际免疫学杂志,2013,36(5):383-387. 被引量：1
2梁华,杨军平,唐艳.Th22细胞及其分泌因子IL-22的研究进展[J].国际免疫学杂志,2013,36(2):116-121. 被引量：10

二级参考文献61

1MossmanTR, Coffman RL. Thl and Th2 cells:different patterns of lymphokines secretion lead to differenffunctional properties. Annu Rev Immunol, 1989, 7: 145-173.
2O' Shea JJ, Paul WE. Mechanisms underlying lineage commitment and plasticity of helper CD4 + T cells. Science, 2010, 327: 1098-1102.
3Duhen T, Geiger R, Jarrossay D, et al. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memo- ry T ceils. Nat Immunol, 2009, 10: 857-863.
4Trifari S, Kaplan CD, Tran EH, et al. Identification of a human helper T cell population that has abundant production of interleu- kin 22 and is distinct from TH-17, TH-1 and TH-2 cells. Nat Im- munol, 2009, 10: 864-871.
5Zhang N, Pan HF, Ye DQ. Th22 in inflammatory and autoim- mune disease: prospects for therapeutic intervention. Mol Cell Biochem, 2011, 353 ( 1-2 ) : 41-46.
6Alam MS, Maekawa Y, Kitamura A, et al. Notch signaling drives IL-22 secretion in CIM + T ceils by stimulating the aryl hydrocar- bon receptor. Proc Natl Acad Sci USA, 2010, 107 (13) : 5943- 5948.
7Kagami S, Rizzo HL, Lee JJ, et al. Circulating Thl7, Th22, and Thl cells are increased in psoriasis. J Invest Dermatol, 2010 , 130 (5) : 1373-1383.
8Dumoutier L, Louahed J, Renauld JC. Cloning and characteriza- tion of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J Immunol, 2000, 164(4) : 1814 - 1819.
9Wolk K, Warszawska K, Hoeflich C, et al. Deficiency of IL-22 contributes to a chronic inflammatory disease:pathogenetic mecha- nisms in acne inverse. J Immunol, 2011, 186(2) : 1228-1239.
10Kerstin W, Ellen W, Katrin W, et al. Biology of interleukin-22. Semin Immunopathol, 2010, 32 ( 1 ) : 17-31.