虹膜后表面色素颗粒对Tenon囊成纤维细胞增生的影响

Effect of pigment granules at the posterior surface of iris on the proliferation of Tenon’s capsule fibroblasts

青光眼是目前最主要的不可逆性致盲眼病之一,以病理性高眼压和视野缺损为主要特点。滤过性手术在青光眼的治疗中具有重要地位,Tenon囊成纤维细胞(Tenon′s capsule fibroblasts,TCF)过度增生导致滤过通道瘢痕化降低了手术的成功率,是滤过性手术失败的根本原因。近年来,有研究提示,虹膜后表面色素颗粒在眼前段的存在有助于抑制TCF增生,为青光眼术中、术后抗瘢痕化处理提供新的思路和研究方向。

Glaucoma is one of the leading course of irreversible blindness worldwide,of which the main characteristics include pathological high intraocular pressure and visual field defect.Filtration surgery plays an important role in the treatment of glaucoma.However,postoperative scarring of the filtration channel resultant from excessive proliferation of Tenon′s capsule fibroblasts(TCFs)reduces the long-term success rate of the surgery.In recent years,it has been suggested that presence of pigment granules in anterior segment of the eyeball may inhibit the proliferation of TCFs,which provides a novel thought and research direction for intro-and postoperative management of scarring in filtration surgery.