固有免疫细胞代谢重编程调控脓毒症免疫稳态的研究进展

Research progress on metabolic reprogramming of innate immune cells involved in immune-regulation of sepsis

免疫抑制引起脓毒症后期死亡风险增加.中性粒细胞、单核/巨噬细胞、自然杀伤细胞(NK细胞)和树突细胞等固有免疫细胞功能失调与脓毒症免疫抑制有关.近年来,免疫细胞代谢重编程是研究脓毒症免疫调节的热点问题.本文以固有免疫细胞为切入点,分析总结中性粒细胞脂肪酸合成代谢、单核/巨噬细胞葡萄糖和精氨酸代谢、NK细胞"驯化"与糖酵解、糖脂代谢、线粒体合成以及树突细胞分化、成熟、活化进行综述,以期深入理解脓毒症免疫代谢调节机制.

Immunosuppression plays a critical role in death of sepsis. Innate immunity is the first line defense to prevent pathogen invasion, and neutrophils, macrophages, dendritic cells and natural killer cells (NK cells) are closely involved in the process of the immune-regulation during sepsis. Recently, metabolic reprogramming in immune cells is known as a keystone for immune intervention therapy in sepsis. Here, we focus on the recent advances in metabolic regulation in neutrophils, macrophages, dendritic cells and NK cells including glycolysis, fatty acid synthesis, fatty acid oxidation and arginine metabolism involved in the immune-regulation of sepsis. This review will be helpful to summarize the mechanisms underlying sepsis-induced immunosuppression.