金翘热毒清颗粒治疗小儿疱疹性咽峡炎发热临床研究

Observation on the effect of Jinqiao-Reduqing granule for hte children with herpetic angina fever

目的评价金翘热毒清颗粒治疗疱疹性咽峡炎发热患儿的疗效。方法将符合入选标准的90例疱疹性咽峡炎患儿按随机数字表法分为2组,每组45例。在对症支持治疗基础上,对照组服用利巴韦林颗粒,观察组服用金翘热毒清颗粒。2组均连续治疗4 d。分别于治疗前后进行症状、体征评分;观察并记录患儿退热时间、疱疹消退时间、流涎消失时间、食欲恢复时间;采用ELISA法检测血清IL-2、IL-6、IL-10、TNF-a水平,采用流式细胞仪检测外周血CD4+、CD8+水平,计算CD4+/CD8+比值。结果治疗后,观察组症状、体征评分[(3.02±2.89)分比(6.88±2.31)分,t=6.999]低于对照组(P<0.01);退热时间[(16.8±3.2)h比(29.9±4.4)h,t=16.202]、疱疹消退时间[(72.3±5.4)h比(96.7±6.2)h,t=19.765]、流涎消失时间[(26.4±2.0)h比(46.3±3.6)h,t=32.479]、食欲恢复时间[(19.6±4.2)h比(39.7±4.9)h,t=20.907]均早于对照组(P<0.01)。观察组治疗后血清IL-2、IL-6、IL-10、TNF-a水平均低于对照组(t值分别为4.974、4.410、6.447、4.767,P值均<0.01);CD4+水平、CD4+/CD8+比值均高于对照组(t值分别为4.033、6.860,P值均<0.01),CD8+水平低于对照组(t=4.928,P<0.01)。结论金翘热毒清颗粒可使疱疹性咽峡炎发热患儿的症状消退时间缩短,炎性细胞因子水平降低,机体免疫力提高。

Objective To evaluate the effect of Jinqiao-Reduqing granule in the treatment of children with herpes angina fever. Methods A total of 90 children with herpes angina were randomly divided into two groups, with 45 cases in each group. Both groups received the symptom-supported treatment. On this basis, the control group took ribavirin granules, while the observation group took Jinqiao-Reduqing granule. Both groups were treated for 4 days. The symptoms and signs were scored before and after treatment. The fever abatement time, herpes subsidence time, salivation disappearance time and appetite recovery time were observed and recorded. The serum levels of IL-2, IL-6, IL-10 and TNF-a were detected by ELISA, and peripheral blood levels of CD4+, CD8+, CD4+/CD8+ were detected by flow cytometry. Results After treatment, the scores of symptoms and signs in the observation group were significantly lower than those in the control group (3.02 ± 2.89 vs. 6.88 ± 2.31;t=6.999, P<0.01). The time of fever abatement (16.8 ± 3.2 h vs. 29.9 ± 4.4 h, t=16.202), herpes subsidence (72.3 ± 5.4 h vs. 96.7 ± 6.2 h, t=19.765), salivation disappearance (26.4 ± 2.0 h vs. 46.3 ± 3.6 h, t=32.479) and appetite recovery (19.6 ± 4.2 h vs. 39.7 ± 4.9 h, t=20.907) were significantly earlier than those in the control group (P<0.01). After treatment, the serum levels of IL-2, IL-6, IL-10 and TNF-a in the observation group were lower than those in the control group (t were 4.974, 4.410, 6.447 and 4.767, respectively, all Ps<0.01);CD4+ levels and CD4+/CD8+ were significantly higher than those in the control group (t were 4.033, 6.860, all Ps< 0.01), and CD8+ levels was significantly lower than those in the control group (t=4.928, P<0.01). Conclusions The Jinqiao-Reduqing granule can shorten the time of symptoms subsidence, reduce the level of inflammatory cytokines and improve the immunity of children with herpes angina fever.