针刺联合明目地黄丸治疗干眼症临床研究

The clinical effects of acupuncture combined with Mingmu-Dihuang pill on dry eyes

目的评价针刺联合明目地黄丸治疗干眼症的疗效。方法将符合入选标准的干眼症患者100例采用随机数字表法分为2组。每组50例各100只眼。观察组采用口服明目地黄丸联合针刺治疗,对照组用玻璃酸钠滴眼液滴眼。2组均治疗2个月。观察角膜荧光素染色试验(fluorescent test, FL)、泪膜破裂时间(breakup time of tear film, BUT)、基础泪液分泌试验(schirmer I test, SIT)变化,评价临床疗效。结果观察组总有效为89.0%(89/100)、对照组为67.0%(67/100),2组比较差异有统计学意义(χ2=14.121,P<0.001)。治疗后,观察组BUT[(7.89±1.65)s比(5.01±1.72)s,t=8.541]大于对照组(P<0.01),SIT[(7.45±1.68)mm比(5.57±1.45)mm,t=5.991]高于对照组(P<0.01),FL评分及眼部症状评分均低于对照组(t值分别为11.551、12.342,P<0.01)。结论针灸联合明目地黄丸治疗干眼症,可有效改善患者的临床症状,提高临床疗效。

Objective To evaluate the effect and safety of acupuncture combined with Mingmu-Dihuang pill in patients with dry eyes. Methods A total of 100 patients with dry eye were enrolled in line with the inclusion criteria and divided into experimental group and control group by random figure table. The experimental group was treated with acupuncture combined with Mingmu-Dihuang pill, and the control group was treated with artificial tears. After 2 months of treatment, the Schirmer test (schirmerI, SIT), tear film break up time (BUT), fluorescent staining (FL) and clinical symptom score were observed and compared, and the clinical efficacy and safety were evaluated. Results The total effective rate of the experimental group was 89.0%(89/100) and the control group was 67.0%(67/100), and the difference was significant (χ2=14.121, P<0.001). After treatment, the levels of BUT (7.89 ± 1.65 s vs. 5.01 ± 1.72 s, t=8.543), SIT (7.45 ± 1.68 mm vs. 5.01 ± 1.72 mm, t=5.991) in the experimental group were significantly higher than those of the control group, and the difference is significant (P<0.01). The FL score and dry eye score in the experimental group were significantly lower than those of the control group (t were 11.551, 12.342, P<0.01). Conclusions Acupuncture combined with Mingmu-Dihuang pill has better clinical effect and good safety for the treatment of dry eye patients.