摘要
FHL2是一种参与信号转导和基因转录的支架蛋白,具有FHL蛋白典型的结构特征.FHL2含有四个半LIM结构域,不同的LIM结构域可以与不同的蛋白质结合,从而激活或者抑制转录因子如P53、血清应答因子等的活性,进而影响肿瘤的发生发展.既往研究发现,FHL2在肿瘤发生发展中具有复杂的生物学作用,在不同类型肿瘤中发挥促癌或抑癌的作用.本文就FHL2在消化系统恶性肿瘤中的研究进展作一概述.
FHL2 is a scaffold protein that regulates signal transduction and gene transcription,and it has typical structural features of FHL proteins.Each FHL protein contains four half-LIM domains,and different LIM domains can bind to different proteins,which can activate or inhibit the activities of transcription factors such as P53 and serum response factors,and then influences the development of tumors.Previous studies have found that FHL2 has a complex biological role in tumorigenesis,and may promote or suppress tumor development in different types of tumors.In this article,we review the role of FHL2 in digestive system malignancies.
作者
朱翠翠
康海锋
仇建伟
钱俊波
刘宏斌
张冬梅
Cui-Cui Zhu;Hai-Feng Kang;Jian-Wei Qiu;Jun-Bo Qian;Hong-Bin Liu;Dong-Mei Zhang(Department of Gastroenterology and Hepatology,the Second Affiliated Hospital of Nantong University,Nantong 226000,Jiangsu Province,China;Department of Pathology,the Second Affiliated Hospital of Nantong University,Nantong 226000,Jiangsu Province,China;Clinical Medical Research Center,the Second Affiliated Hospital of Nantong University,Nantong 226000,Jiangsu Province,China)
出处
《世界华人消化杂志》
CAS
2019年第17期1083-1087,共5页
World Chinese Journal of Digestology
