摘要
BACKGROUND Calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor that often occurs in deep soft tissue of children and young adults.CFT rarely occurs in the mediastinum.CASE SUMMARY In this paper,we describe a 31-year-old male patient with CFT in the mediastinum.The patient did not have any symptoms,and the posterior mediastinal lesion was unintentionally found during routine re-examination of thyroid cancer.The tumor had no adhesion to the surrounding tissue and was successfully and completely removed.Pathology showed a large amount of collagen-rich fibrous connective tissue.There was scattered dystrophic calcification and gravel in the fibrous tissue and a small amount of lymphocyte and plasma cell infiltration and lymphoid follicle formation in the interstitial fluid.In addition,findings showed 20 IgG4+ plasma cells per high-powered field of the diseased tissue,an IgG4+/IgG ratio of about 20%,and normal serum IgG4 levels.The final diagnosis was CFT of the mediastinum (CFTM).No evidence of tumor recurrence was observed by computed tomography at 3 mo after surgery.CONCLUSION IgG4+ plasma cell enlargement may occur in CFTM,but clinical manifestations and serological tests suggest that it is not IgG4-related disease.We speculate that it may be an independent tumor subtype.
BACKGROUND Calcifying fibrous tumor(CFT) is a rare benign mesenchymal tumor that often occurs in deep soft tissue of children and young adults. CFT rarely occurs in the mediastinum.CASE SUMMARY In this paper, we describe a 31-year-old male patient with CFT in the mediastinum. The patient did not have any symptoms, and the posterior mediastinal lesion was unintentionally found during routine re-examination of thyroid cancer. The tumor had no adhesion to the surrounding tissue and was successfully and completely removed. Pathology showed a large amount of collagen-rich fibrous connective tissue. There was scattered dystrophic calcification and gravel in the fibrous tissue and a small amount of lymphocyte and plasma cell infiltration and lymphoid follicle formation in the interstitial fluid. In addition, findings showed 20 Ig G4+ plasma cells per high-powered field of the diseased tissue, an Ig G4+/Ig G ratio of about 20%, and normal serum Ig G4 levels. The final diagnosis was CFT of the mediastinum(CFTM). No evidence of tumor recurrence was observed by computed tomography at 3 mo after surgery.CONCLUSION Ig G4+ plasma cell enlargement may occur in CFTM, but clinical manifestations and serological tests suggest that it is not Ig G4-related disease. We speculate that it may be an independent tumor subtype.
基金
Supported by Natural Science Foundation of Liaoning Province in China,No.81572621 and No.2019-MS-370
