非酒精性脂肪性肝病和结直肠肿瘤的关系

Association between nonalcoholic fatty liver disease and colorectal tumors

近年研究认为非酒精性脂肪性肝病为代谢综合征的肝脏表现,与促结直肠瘤变的因素--肥胖、胰岛素抵抗、高血压、高血脂等有关。提出了非酒精性脂肪性肝病与结直肠肿瘤的发生发展密切相关,归纳总结了非酒精性脂肪性肝病和结直肠肿瘤的关系及可能的互相影响机制,指出二者在临床、发病机制等方面存在不同程度的交叉,希望对这一领域未来的研究提供一定的参考。

Recent studies have shown that nonalcoholic fatty liver disease( NAFLD) is the manifestation of metabolic syndrome in the liver and is associated with the factors which promote colorectal neoplasia,such as obesity,insulin resistance,hypertension,and hyperlipidemia.This article points out that NAFLD is closely associated with the development and progression of colorectal tumors and summarizes the association between NAFLD and colorectal tumors and possible mechanisms.It is pointed out that NAFLD and colorectal tumors share certain clinical features and pathogenesis,which provides a theoretical basis for future research in this field.