2型固有淋巴细胞在肝脏疾病免疫调控中的作用

Role of type 2 innate lymphoid cells in immunoregulation of liver diseases

固有淋巴细胞(ILCs)是新发现的一类固有免疫细胞,2型固有淋巴细胞(ILC2s)是其中一个细胞亚群,在受到IL-25、IL-33等刺激后可产生2型辅助型T淋巴细胞(Th2)因子,具有启动和维持2型免疫反应的作用。ILC2s属于固有免疫细胞,又具有调节适应性免疫的功能,参与炎症、组织修复、细胞增殖、代谢、调节免疫等病理生理过程。肝脏是人体重要的代谢器官和免疫器官,含有多种免疫细胞。ILC2s在肝脏疾病中具有调节免疫、调控炎症以及组织修复等重要作用。总结了ILC2s的生理功能及其在肝脏疾病发病机制中的免疫调控机制。

Innate lymphoid cells( ILCs) are a new type of innate immune cells discovered in recent years,and type 2 ILCs( ILC2 s) are a subset of ILCs and can produce type 2 T-helper cytokines after being activated by interleukin-25 and interleukin-33,which helps to start and maintain type 2 immune response.ILC2 s belong to innate immune cells and can regulate adaptive immunity and participate in various pathophysiological processes such as inflammation,tissue repair,cell proliferation,metabolism,and immunoregulation.The liver is recognized as an important metabolic and immune organ in the human body and contains several types of immune cells.ILC2 s can regulate immune response,inflammation,and tissue repair in liver diseases.This article summarizes the physiological function of ILC2 s and the immunomodulatory mechanism of ILC2 s in liver disease.