安宫牛黄丸联合磷酸肌酸钠对新生儿窒息并心肌损伤患者的临床疗效

Clinical effects of Angong Niuhuang Pills combined with sodium phosphocreatine on patients with asphyxia neonatorum and myocardial injury

目的探讨安宫牛黄丸联合磷酸肌酸钠对新生儿窒息并心肌损伤患者的临床疗效。方法 95例患者随机分为对照组(45例)和观察组(50例),对照组给予磷酸肌酸钠,观察组在对照组基础上加用安宫牛黄丸,疗程1周。然后,检测临床疗效、血气分析指标[血氧分压(PaO2)、二氧化碳分压(PaCO2)、氧合指数(PaO2/FiO2)]、心肌酶谱[谷草转氨酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)]、基本症状改善时间、不良反应发生率变化。结果观察组总有效率、PaO2水平、PaO2/FiO2显著高于对照组(P<0.05),PaCO2水平、心肌酶谱显著降低(P<0.05),基本症状改善时间显著缩短(P<0.05)。2组不良反应发生率无显著差异(P>0.05)。结论安宫牛黄丸联合磷酸肌酸钠可有效改善新生儿窒息并心肌损伤患者缺氧状态和心肌损伤,促进症状恢复,安全性较高。

AIM To explore the clinical effects of Angong Niuhuang Pills combined with sodium phosphocreatine on patients with asphyxia neonatorum and myocardial injury. METHODS Ninety-five patients were randomly divided into control group(45 cases) for 1-week administration of sodium phosphocreatine, and observation group(50 cases) for 1-week administration of Angong Niuhuang Pills and sodium phosphocreatine. Subsequently, the changes in clinical efficacy, blood gas analysis indices[partial pressure of blood oxygen(PaO2), partial pressure of carbon dioxide(PaCO2), oxygenation index(PaO2/FiO2)], myocardial enzyme spectra[aspartate aminotransferase(AST), creatine kinase(CK), creatine kinase isoenzyme(CK-MB), lactate dehydrogenase(LDH),α-hydroxybutyrate dehydrogenase(α-HBDH)], improvement time of basic symptoms and occurrance rate of adverse reactions were detected. RESULTS The observation group demonstrated significantly higher total effective rate, PaO2 level and PaO2/FiO2 than the control group(P<0.05), as well as markedly decreased PaCO2 level and myocardial enzyme spectra(P<0.05), in addition to obviously shortened improvement time of basic symptoms(P<0.05). No significant difference in the occurrance rate of adverse reactions was observed between the two groups(P>0.05). CONCLUSION For the patients with asphyxia neonatorum and myocardial injury, Angong Niuhuang Pills combined with sodium phosphocreatine can effectively improve hypoxic state and myocardial injury, and promote symptom recovery, with high safety.