云南地区7046例男性精液质量和年龄关系的探讨

The relationship between male semen quality and age among 7046 males in Yunnan

目的讨论云南地区男性年龄对精液质量的影响,建议云南男性合适生育年龄,提高优生优育。方法选择1-9月期间来我院生殖遗传科实验室进行精液检测的7046例患者作为研究对象,分析男性精液质量情况,并根据年龄进行分组,≤25岁、25岁~30岁、30岁~35岁、35岁~40岁、>40岁,共5组,分析比较各组精液参数。结果 7046例男性患者中,精液质量分析均正常者占54.04%(3808/7046);精液质量异常者占45.96%(3238/7046),无精子症患者占5.52%(389/7046)。与正常组相比,异常组的精子活力、精液密度、精液量有极显著差异(P<0.01),而液化时间无差异(P>0.05)。>40岁组与其他组相比,其总活力(PR+NP)、前向运动精子(PR)、精子密度、精液量、液化时间具有极显著差异(P<0.01)。虽然精子活力在35岁时开始下降,但35岁以前无显著差异,精子活力在40岁以后下降趋势明显且具有显著差异(P<0.01);而精液密度和液化时间随年龄的增高而增高。结论云南地区男性精液质量随着年龄的增加而下降,精子活力在35岁时开始下降,在40岁以后下降明显且具有显著差异,提示云南地区男性的最佳生育年龄在35岁以前。

Objective:To investigate the relationship between male semen quality and age in Yunnan,and provide males in Yunnan for suitable reproductive age and improve prenatal and postnatal care. Methods:7046 males patients treated in the Department of Reproductive Genetics in our hospital from January to September were selected as subjects. The quality of male semen was analyzed and divided into five groups according to age,≤ 25 years old,25 years old to 30 years old,30 years old to 35 years old,35 years old to 40 years old,and >40 years old. and the semen parameters of each group were analyzed and compared. Results:Among 7046 male patients,the normal semen quality analysis was 54.04%(3808/7046);the abnormal semen quality was 45.96%(3238/7046),and the azoospermia accounted for 5.52%(389/7046). Compared with the normal group,there was a significant difference in sperm motility,semen density,and semen volume in the abnormal group(P<0.01),but there was no difference in liquefaction time(P>0.05). Compared with other groups,the total activity(PR+NP),PR sperm,sperm density,semen volume,and liquefaction time of the 40-year-old group were significantly different(P<0.01). Although sperm motility began to decline at the age of 35,there was no significant difference before the age of 35. The sperm motility decreased significantly after 40 years of age and had significant differences(P<0.01);while semen density and liquefaction time increased with age. Conclusion:The semen quality of males in Yunnan decreased with age,and the sperm motility began to decrease at the age of 35. After 40 years of age,the decline was significant,suggesting that the best reproductive age of males in Yunnan is before the age of 35.