控制性超促排卵过程中相关因子与卵母细胞质量关系的研究进展

Relationships between serum and follicular fluid related factors and oocyte quality in controlled ovarian hyperstimulation

体外受精-胚胎移植(IVF-ET)过程中,卵母细胞质量对于受精、早期胚胎发育、妊娠建立和维持以及胎儿发育产生着深远影响,正确评估卵母细胞质量对于改善IVF-ET结局具有重要意义。目前,关于卵母细胞质量的评估方法有很多种,其中血清及卵泡液中相关因子如胰岛素样生长因子系统(IGFs)、抑制素B(INHB)、抗苗勒氏管激素(AMH)及血管内皮生长因子(VEGF)等在评估卵母细胞质量中的价值备受关注。关于这些因子的深入研究,有望成为评估卵母细胞质量的重要工具。

Oocyte quality has a profound impact on fertilization,early embryonic develop-ment,pregnancy estabilishement and maintenace as well as fetal development in in vitro fertilization-embryo transfer(IVF-ET)and the correct evaluation of oocyte quality is of critical significance for improving the outcome of IVF-ET. To date,there are a lot of methods of assessing oocyte quality,among them,the value of serum and follicular fluid(FF)related factors such as insulin-like growth factor system(IGFs),inhibin B(INHB),anti-mullerian hormone(AMH),vascular endothelial growth factor(VEGF)and so on in evaluation of oocyte quality has attracted much attention. Futher researches on these foctors are expected to become important tools to assess the quality of oocyte.