钛种植体纳米管改性促成骨作用研究进展

Research progress on ossification by titanium nanotube implant modification

对纯钛种植体进行表面改性以提高其骨结合能力是牙科种植术研究的热点。目前,纯钛表面改性的方法主要有物理法、化学法、生物法和阳极氧化法,其中阳极氧化法可以形成结构均一稳定的TiO2纳米管结构,TiO2纳米管与基底具有较高的结合强度和成骨性能,是一种优良的种植体改性方法。TiO2纳米管成骨作用与其形貌、直径及理化表征密切相关,因此可通过调控这些因素制备出成骨性能更优的TiO2纳米管结构。目前学者对TiO2纳米管的研究多聚焦于TiO2纳米管的复合处理方向,即将种植体其他改性方法(物理法、化学法、生物法)与TiO2纳米管联用形成复合结构,以协同发挥成骨作用。TiO2纳米管复合处理技术为进一步制备成骨性能较强的TiO2纳米管改性结构提供良好的应用前景。

Surface modification of titanium implants is a hot topic for improving osteointegration and includes physical, chemical, bioactive and anodization methods. Among these methods, anodization methods can form TiO2 nanotube structures with a uniform and stable structure, and TiO2 nanotubes and substrates have high binding strengths and osteogenic properties and represent an excellent method for implant modification. TiO2 nanotube osteogenesis is closely related to its morphology, diameter and physicochemical characteristics. Therefore, the structure of TiO2 nanotubes with optimal osteogenic performance can be prepared by regulating these factors. At present, research on TiO2 nanotubes is mostly focused on composite treatments with TiO2 nanotubes, namely, the combination of other implant modification methods(physical method, chemical method, biological method) and TiO2 nanotubes to form a composite structure to work synergistically to treat osteogenesis. TiO2 nanotube composite treatment is a good prospective application for the further preparation of TiO2 nanotube-modified structures with strong osteogenic properties.