糖化血清白蛋白水平与不稳定型心绞痛患者择期经皮冠状动脉介入术后发生造影剂肾病的关系

Association of glycated albumin with contrast-induced nephropathy after selective percutaneous coronary intervention in patients with unstable angina pectoris

目的探讨糖化血清白蛋白(GA)水平与不稳定型心绞痛(UA)患者择期经皮冠状动脉介入(PCI)术后发生造影剂肾病(CIN)的关系。方法收集2018年1—12月在首都医科大学附属北京安贞医院诊断为UA并接受PCI治疗的420例患者的病历资料。根据GA水平分为观察组(GA≥17.1%,118例)和对照组(GA<17.1%,302例),比较2组患者术前及术后36h血肌酐水平、内生肌酐清除率(CCr)及CIN发生率,分析GA水平与UA患者择期PCI术后发生CIN的关系。结果观察组CIN发生率高于对照组[30.5%(36/118)比7.0%(21/302)],差异有统计学意义(P<0.01)。Logistic回归分析结果表明GA≥17.1%是PCI术后发生CIN的独立危险因素(比值比=5.711,95%置信区间2.475~13.785,P<0.001)。结论诊断UA行择期PCI治疗患者中,GA≥17.1%患者术后CIN发生率将明显升高。

Objective To investigate the association of glycated albumin(GA)with contrast-induced nephropathy(CIN)after selective percutaneous coronary intervention(PCI)in patients with unstable angina pectoris(UA).Methods Clinical data of 420 UA patients who had PCI in Beijing Anzhen Hospital,Capital Medical University from January to December 2018 were collected.They were divided into observation group(GA≥17.1%,118 cases)and control group(GA<17.1%,302 cases).Serum creatinine level and creatinine clearance rate(CCr)before and 36 h after PCI,and the incidence of CIN following PCI were observed.Relation between GA level and CIN was analyzed.Results The incidence of CIN in observation group was significantly higher than that in control group[30.5%(36/118)vs 7.0%(21/302)](P<0.01).Logistic regression indicated that GA≥17.1%was an independent risk factor of CIN(odds ratio=5.711,95%confidence interval:2.475-13.785,P<0.001).Conclusion UA patients with GA≥17.1%have high risk of CIN following selective PCI.