妇康宁颗粒的药效学研究

Pharmacodynamics of Fukangning Granules

目的研究妇康宁颗粒剂的药效学。方法采用小鼠扭体法和热板法考察妇康宁颗粒的镇痛作用,采用小鼠耳肿胀法和大鼠纸片包埋法考察妇康宁颗粒的抗炎作用,采用小鼠凝血时间、出血时间试验考察妇康宁颗粒的止血作用,采用小鼠碳廓清试验考察妇康宁颗粒调节免疫作用。结果妇康宁颗粒对化学、物理刺激引发的疼痛具有良好的抑制作用。妇康宁颗粒剂对急性渗出性炎症和慢性增殖性炎症具有一定的抑制作用,具有剂量相关性。妇康宁颗粒剂具有一定的凝血和止血作用。妇康宁颗粒可以促进小鼠免疫器官的发育,增加小鼠单位时间清除血液异物的速度。结论妇康宁颗粒具有抗炎、止血、调节免疫作用,为临床应用提供了科学的依据。

Objective To study the pharmacodynamics of Fukangning Granules. Methods Writhing test and hot plate test in mice were used to study analgesic effect of Fukangning Granules. Ear swelling test in mice and paper embedding method in rats were used to study anti-inflammatory effect. Blood coagulation and bleeding tests in mice were used to study hemostatic effect. Carbon clearance test in mice were used to study immune effect. Results Fukangning Granules have analgesic effect, which has a certain inhibitory effect on the pain of mice caused by physical stimulation and chemical stimulation. Fukangning Granules have good inhibitory effects on acute exudative inflammation and chronic proliferative inflammation. Fukangning Granules have certain coagulation and hemostasis effects. Fukangning Granules can promote the development of immune organs in mice and increase the speed of clearing blood foreign bodies per unit time in mice. Conclusion Fukangning Granules have anti-inflammatory, hemostatic and immunomodulatory effects, which provides a scientific basis for clinical application.