孕前母亲肥胖对子代神经心理发育影响研究进展

Research progress on the effect of maternal pre-pregnancy obesity on neuropsychological development of offspring

成年女性肥胖是全球性的公共卫生问题。母亲孕前肥胖可能会对子代的认知功能和智力发育产生不良影响,并增加子代出现行为问题、注意力缺陷和多动障碍(attention deficit hyperactivity disorder,ADHD)以及孤独症谱系障碍(autism spectrum disorders,ASD)等的风险。孕前母亲肥胖对子代神经心理发育影响的具体机制尚未被完全理解,可能与脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)、子代大脑代谢改变及炎症等有关。本文对孕前母亲肥胖对子代神经心理发育影响及可能机制作以简要综述,呼吁相关部门及医务人员积极预防母亲孕前肥胖发生,以促进后代身心健康发展。

Obesity in adult women is a global public health problem. Maternal pre-pregnancy obesity may have adverse effects on cognitive function and mental development of offspring and increase the risk of offspring’s behavioral problems, attention deficit and hyperactivity disorder(ADHD) and autism spectrum disorders(ASD). The specific mechanism of maternal pre-pregnancy obesity on the neuropsychological development of offspring is not clear, brain-derived neurotrophic factor(BDNF), the changes in offspring’s brain metabolism and inflammation may be involved in it. This article briefly reviews the effect of maternal pre-pregnancy obesity on the neuropsychological development of offspring and the related mechanism, and calls on relevant departments and medical staff to actively prevent maternal pre-pregnancy obesity so as to promote the healthy development of offspring.