纳米碳在胃癌淋巴结清扫过程中效果的meta分析

Meta-analysis of the effect of nanocarbon in lymph node dissection of gastric cancer

目的探讨纳米碳对于胃癌患者的临床实用性及安全性,评价其在胃癌根治术中的应用价值。方法检索PubMed、Embase、Cochrane Library、中国期刊全文数据库(CNKI)以及万方数据库自建库以来至2019年2月期间收录的与胃癌根治术中纳米碳示踪与非纳米碳示踪比较的相关文献,提取2组患者的淋巴结检出数、淋巴结检出时间、淋巴结转移数及术后并发症数据,采用RevMan 5.3软件进行meta分析。结果共检索出文献88篇,入选10篇。其中5项随机对照研究,5项病例对照研究;纳米碳组784例,非纳米碳组695例。mate分析结果显示,与非纳米碳组比较,纳米碳组的术中淋巴结检出数较多,淋巴结检出时间较短,淋巴结转移数较多,差异均具有统计学意义(P<0.05);而对术后并发症,2组的并发症发生率比较差异无统计学意义(P>0.05)。结论纳米碳对胃癌淋巴结有明显的示踪作用,可降低术中淋巴结检出难度,提高淋巴结检出率,避免传统淋巴结清扫手术过程中的盲目性。

Objective To explore the clinical applicability and safety of nanocarbon in patients with gastric cancer, and evaluate its application value in radical gastrectomy. Methods Collectted relevant literatures on radical gastrectomy for nanocarbon scales from the time of construction of the library to February 2019, according to search databases included PubMed, Embase, Cochrane Library, China Journal Full-text Database(CNKI), and Wanfang. The data of lymph node detection, detection time, number of lymph node metastases, and postoperative complications were extracted from the two groups. We systematically evaluated it, and analyzed the two groups by using RevMan 5.3 software.Results We searched 88 articles and selected 10 articles, including 5 randomized controlled trials and 5 case-control studies. There were 784 patients in the nanocarbon group and 695 patients in the non-nanocarbon group. Results of meta analysis on the clinical utility and safety of nanocarbon labeled lymph nodes showed that, the number of lymph node detection, lymph node detection time, and number of lymph node metastases in the nanocarbon group and nonnanocarbon group were statistically significant(P<0.05), they were better in the nanocarbon group. There was no significant difference in postoperative complications between the two groups(P>0.05). Conclusions Nanocarbon has a clear trace effect on lymph nodes of gastric cancer. It can reduce the difficulty of the number of lymph node detection,improve the detection rate of lymph nodes, and avoid blindness during traditional lymph node dissection.