NRP-1在肾透明细胞癌中的表达及其与预后的相关性

Expression of NPR-1 in clear cell renal cell carcinoma and its correlation with prognosis

目的探究神经菌毛蛋白1(NRP-1)在肾透明细胞癌中的表达水平及其对预后的影响。方法单因素方差分析比较NRP-1在肾透明细胞癌组织(523例)与对应正常组织(100例)的表达差异,及肾透明细胞癌不同病理分期NRP-1的表达差异。根据NRP-1的表达量,以四分位法,将患者分为高表达组(129例)和低表达组(129例),比较两组总生存率和无事件生存率的差异。结果 NRP-1在肾透明细胞癌组织中的表达量显著高于对应的正常组织(128.22 TPM vs 46.29TPM, P <0.01),且NRP-1在Stage I期的表达量较StageⅡ~Ⅳ期高(P <0.05)。523例肾透明细胞癌患者中,高表达组的总生存期较低表达组长(P <0.01),而无事件生存率两者比较无显著差异(P> 0.05)。结论 NRP-1在肾透明细胞癌中高表达,但其表达量与病理分期无显著相关性,且NRP-1高表达可能提示预后较好。

Objective To explore the level of Neuropilin-1(NRP-1) expression in clear cell renal cell carcinoma(ccRCC) and its effect on prognosis. Methods One-way analysis of variance(ANOVA) was used to compare difference of NRP-1 expression between ccRCC tissues(523 cases) and corresponding normal tissues(100 cases), and the difference of NRP-1 expression at different pathological stages of ccRCC. The patients were divided into high-expression group(129 cases) and low-expression group(129 cases)according to quartiles of the level of NRP-1 expression. Comparison was made between the two groups in terms of the overall survival rate and event-free survival rate. Results The level of NRP-1 expression in ccRCC tissues was significantly higher than that in normal tissues(128.22 TPM vs 46.29 TPM, P < 0.01). The average level of NRP-1 expression in Stage I was higher than that in StageⅡ-Ⅳ(P < 0.05). Among the 523 patients with ccRCC, the overall survival in the high-expression group was longer than that in the lower-expression group(Log-rank test, P < 0.01), while there was no significant difference in the event-free survival rate between the two groups(P > 0.05). Conclusion NRP-1 is highly expressed in ccRCC, but its expression level is not significantly correlated with pathological stage. High expression of NRP-1 may suggest a better prognosis.