贝前列素联合黛力新治疗偏头痛的疗效及作用机理研究

Efficacy and mechanism of Beraprost combined with Deanxit in treatment of migraine

目的研究贝前列素联合黛力新治疗偏头痛的疗效及作用机理。方法将80例偏头痛患者随机分为两组,A组采用黛力新治疗,B组于A组基础上联合贝前列素钠治疗,比较两组治疗效果,以及治疗前后血浆5-羟色胺、β内啡肽、神经降压素水平及不良反应。结果 B组治疗总有效率高于A组(P <0.05);治疗后,两组偏头痛发作次数、持续时间、疼痛VAS评分、血浆5-羟色胺和神经降压素水平均降低,β内啡肽水平均升高,且B组改善幅度均大于A组(P <0.05);两组不良反应比较无统计学差异(P> 0.05)。结论贝前列素钠联合黛力新可提高治疗偏头痛的临床疗效,其作用机理可能与降低血浆5-羟色胺和神经降压素水平及升高β内啡肽水平有关,且临床应用安全,值得推广。

Objective To study the efficacy and mechanism of Beraprost combined with Deanxit in treatment of migraine.Methods A total of 80 migraine patients were randomly divided into group A and group B. Deanxit was performed on Group A,beraprost sodium combined with Deanxit was performed on group B. Comparison was made between the two groups with respect to efficacy, adverse reactions, along with levels of plasma 5-hydroxytryptamine(5-HT), β-Endorphin and neurotensin before and after treatment. Results The total effective rate of group B was higher than that of group A(P < 0.05). After treatment, the frequency of migraine attacks, duration of migraine, pain VAS score, levels of plasma 5-HT and neurotensin were reduced in both groups, and theβ-Endorphin levels in both groups were increased. The improvement of group B was greater than that of group A(P < 0.05). There was no statistically significant difference in adverse reactions between the two groups(P > 0.05). Conclusion Beraprost sodium combined with Deanxit can improve the clinical efficacy in treatment of migraine. Its mechanism may be related to the decline of levels of plasma 5-HT and neurotensin and the increase of β-Endorphin level. The therapy is worthy to be popularized for its safety in clinical application.