强化瑞舒伐他汀联合阿司匹林对早期进展型脑梗死的效果评价

Evaluation of clinical effective of intensive rosuvastatin combined with aspirin on patients with early progressive cerebral infarction

目的探讨强化瑞舒伐他汀联和阿司匹林对早期进展型脑梗死患者的临床疗效及对血清高敏C反应蛋白(high sensitivity C reactive protein,hs CRP)、D 二聚体(D dimer)的影响。方法选取宿迁市第一人民医院住院治疗的早发进展型脑梗死患者73例,随机分为对照组35例和试验组38例。对照组给予瑞舒伐他汀10 mg及阿司匹林 300 mg(1周后减为100 mg);试验组给予瑞舒伐他汀20 mg及阿司匹林300 mg(1周后减为100 mg),分别在入院后第1天、3天及第14天监测患者血清hs CRP、D 二聚体含量,第3天、第14天及第8周时评估NIHSS评分,第14天及第8周时评估改良Batherl评分。结果进展型脑梗死患者血hs CRP在梗死后第3天达到高峰,D 二聚体在梗死后第14天达到高峰,强化瑞舒伐他汀在梗死后14 d时可显著减少血清hs CRP及D 二聚体水平,且在8周时能显著改善神经功能缺损症状。结论强化瑞舒伐他汀可降低早期进展型脑梗死患者hs CRP及D 二聚体水平,能有效改善急性脑梗死患者预后。

Objective To investigate the clinical efficacy of intensive rosuvastatin combined with aspirin in the treatment of early progressive cerebral infarction and its effect on serum hs CRP and D dimer. Methods 73 patients with early progressive cerebral infarction hospitalized in the First People's Hospital of Suqian were randomly were randomly divided into control group (35 cases) and treatment group (38 cases).The control group was given rosuvastatin 10 mg and aspirin 300 mg (reduced to 100 mg a week later),while the treatment group was given rosuvastatin 20 mg and aspirin 300 mg (reduced to 100 mg a week later).The amount of serum CRP and D dimer was measured by using an automatic biochemical analyzer during the next day (day 1),day 3,and day 14 after being admitted to hospital.National Institutes of Health Stroke Scale (NIHSS) were also recorded at day 3,day 14 and eighth week,and the modified Batherl scores were compared at day 14 and eighth week. Results The levels of hs CRP in patients with progressive cerebral infarction reached the peak at the third day and and D dimer reached the peak at the fourteenth day after infarction.The levels of hs CRP and D dimer in patients with progressive cerebral infarction were significantly reduced by enhanced rosuvastatin on the fourteenth day after infarction,and the symptoms of neurological impairment were significantly improved at the eighth week. Conclusion Enhanced rosuvastatin can reduce the levels of hs CRP and D dimer in patients with progressive cerebral infarction,effectively improve the prognosis of patients with acute cerebral infarction.