血管性认知功能损害脑CT灌注成像与认知功能的关系

Correlation between cerebral CT perfusion imaging and cognitive function in patients with vascular cognitive impairment

目的探讨血管性认知功能损害患者脑CT灌注成像特征,分析其与认知功能的相关性。方法 2016 06—2018 06在焦作市第二人民医院住院诊治的缺血性脑卒中患者112例进行蒙特利尔认知评估量表(MoCA)测验,依据测试结果分为认知功能正常者46例和不正常者66例,认知功能不正常者进一步分为血管性非痴呆认知功能损害(vascular cognitive impairmentno dementia,V CIND)组48例和血管性痴呆(VaD)组18例,分析各组患者脑CT灌注成像特征,以及与认知功能的相关性。结果本次入组112例脑卒中患者VCI发生率为58.93%。脑血容量(CBV)及脑血流量(CBF)指标3组间比较差异有意义( P <0.05);CBV和CBF与MoCA评分呈正相关( P <0.05),与连线测验完成时间呈负相关( P <0.05)。结论认知障碍患者均存在不同程度的脑血流灌注降低,且随着认知功能进展血流灌注进一步下降,脑计算机断层灌注成像可早期识别VCI,为临床诊治提供依据。

Objective To explore the CT perfusion imaging features of patients with vascular cognitive impairment and analyze its correlation with cognitive function.Methods We selected 112 patients with ischemic stroke hospitalized in our hospital from June 2016 to June 2018 as the subjects of this study,and conducted the Montreal Cognitive Assessment Scale(MoCA) test.According to the test results,the subjects were divided into 46 cases with normal cognitive function and 66 cases with abnormal cognitive function.Those with abnormal cognitive function were further divided into 48 cases in V-CIND group and 18 cases in VaD group.The characteristics of CT perfusion imaging and its correlation with cognitive function were analyzed.Results The incidence of VCI in 112 stroke patients was 58.93%.There were significant differences in cerebral blood volume(CBV) and cerebral blood flow(CBF) between the three groups(P<0.05).CBV and CBF were positively correlated with MoCA score(P<0.05) and negatively correlated with completion time of the connection test(P<0.05).Conclusion The cerebral blood flow perfusion of cognitive impairment patients decreased in different degrees,and further decreased with the progress of cognitive function.Head CTP can identify VCI early,which provides a basis for clinical diagnosis and treatment.